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      Circadian Periodicity of Plasma Corticosterone Levels in Rats Subjected to Hemorrhagic Shock and Surgical Trauma

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          The effects of surgical trauma and hemorrhagic shock on the circadian rhythmicity of corticosteroid secretion in the rat were investigated. The estimations were performed at 4-hour intervals for a 24-hour period. Control animals exhibited a characteristic circadian rhythm of plasma corticosterone with peak concentrations occurring at 8 p.m. followed by a gradual fall during the night, reaching a minimum at 8 a.m. Severe stress induced by hemorrhagic shock or surgical trauma caused a dramatic alteration in corticosterone rhythms which persisted up to 72 h following surgery or hemorrhage. It is apparent that the physiological mechanisms which regulate adrenal rhythmicity are disrupted for a prolonged period following major stress or trauma.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 13
          : 6
          : 385-395
          Department of Surgery, Boston University Medical Center, Boston, Mass., USA
          179306 Horm Res 1980;13:385–395
          © 1980 S. Karger AG, Basel

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          Pages: 11
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