Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study.

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Abstract

There are limited treatment options for tissue restoration and the prevention of degenerative changes in the knee. Stem cells have been a focus of intense preclinical research into tissue regeneration but limited clinical investigation. In a randomized, double-blind, controlled study, the safety of the intra-articular injection of human mesenchymal stem cells into the knee, the ability of mesenchymal stem cells to promote meniscus regeneration following partial meniscectomy, and the effects of mesenchymal stem cells on osteoarthritic changes in the knee were investigated.

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Journal

Journal ID (iso-abbrev): J Bone Joint Surg Am

Title: The Journal of bone and joint surgery. American volume

ISSN (Electronic): 1535-1386

ISSN (Print): 0021-9355

Publication date (Electronic): Jan 15 2014

Volume: 96

Issue: 2

Affiliations

[1 ] University of Southern California Orthopaedic Surgery Associates, Keck School of Medicine, 1520 San Pablo Street, Suite 2000, Los Angeles, CA 90033. E-mail address: vangsness@usc.edu.

[2 ] OrthoIndy, 5255 East Stop 11 Road, Suite 300, Indianapolis, IN 46237.

[3 ] TRIA Orthopaedic Center, 8100 Northland Drive, Bloomington, MN 55431.

[4 ] Triangle Orthopaedic Associates, PA, 120 William Penn Plaza, Durham, NC 27704.

[5 ] Osiris Therapeutics, Inc., 7015 Albert Einstein Drive, Columbia, MD 21046.

Article

Publisher Item ID: 1809954

DOI: 10.2106/JBJS.M.00058

PubMed ID: 24430407

SO-VID: 12f30415-a148-47de-9897-eb3173f5070d

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