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      Electrolyte Transport During Ultrafiltration of Protein Solutions

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      Nephron

      S. Karger AG

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          Abstract

          To test the applicability of Gibbs-Donnan diffusion equilibrium formulae to ultrafiltration, we have examined sodium (Na) and chloride (Cl) concentrations in ultrafiltrates collected directly from cellophane and cuprophane coils perfused with albumin-electrolyte solutions in a closed reservoir system. The ratio of ultrafiltrate to perfusate water Na concentration (UF/P Na) and the similar ratio UF/P Cl were 1.0 when albumin concentration was zero. UF/P Na decreased and UF/P Cl increased as albumin concentration was increased and pH maintained at 8.0–8.4. By linear regression, UF/P Cl = 0.017 [albumin (g/l00 ml)] +0.97 and UF/P Na = 0.99–0.011 [albumin]. With a nearly constant circulating albumin concentration (7.4–8.5 g/l00 ml) UF/P Na increased curvilinearly from 0.85 to 1.2 as circulating pH was decreased from 8.7. to 1.8 with HCl, and approached 1.0 near the isoelectric point of albumin (pH = 4.2). Simultaneously UF/P Cl decreased from 1.05 to 0.66 in a similar manner and approached 1.0 at a pH near 7.2. In all studies, measured UF/P Cl was usually less than the reciprocal of UF/P Na. Neither ultrafiltration rate nor the type of membrane used altered UF/P values. We conclude: 1. Protein charge does influence UF Na and Cl concentrations in directions predicted by formulae applicable to diffusion equilibrium; 2. Deviations of UF/P Cl from Gibbs-Donnan and isoelectric predictions are compatible with albumin chloride binding as reported in diffusion studies; 3. The electrolyte composition of filtrates from capillary beds such as glomeruli might be predicted to demonstrate similar deviations from Gibbs-Donnan formulae.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1971
          1971
          26 November 2008
          : 8
          : 5
          : 473-487
          Affiliations
          Department of Medicine, University of Missouri Medical Center, Columbia, Mo.
          Article
          179951 Nephron 1971;8:473–487
          10.1159/000179951
          5130088
          © 1971 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 15
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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