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      Essential involvement of interleukin-8 (IL-8) in acute inflammation.

      1 , , , , ,
      Journal of leukocyte biology

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          Abstract

          Neutrophil infiltration into inflammatory sites is one of the hallmarks of acute inflammation. Locally produced chemotactic factors are presumed to mediate the sequence of events leading to the infiltration at inflammatory sites. Interleukin-8 (IL-8), a novel leukocyte chemotactic activating cytokine (chemokine), is produced by various types of cells upon stimulation with inflammatory stimuli and exerts a variety of functions on leukocytes, particularly, neutrophils in vitro. However, no definitive evidence has been presented on its role in recruiting and activating neutrophils in the lesions of various types of inflammatory reactions. We administered a highly specific neutralizing antibody against IL-8 in several types of acute inflammatory reactions, including lipopolysaccharide (LPS)-induced dermatitis, LPS/IL-1-induced arthritis, lung reperfusion injury, and acute immune complex-type glomerulonephritis. Anti-IL-8 treatment prevented neutrophil-dependent tissue damage as well as neutrophil infiltration in these conditions. These results suggest that IL-8 plays a causative role in acute inflammation by recruiting and activating neutrophils.

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          Author and article information

          Journal
          J Leukoc Biol
          Journal of leukocyte biology
          0741-5400
          0741-5400
          Nov 1994
          : 56
          : 5
          Affiliations
          [1 ] Department of Pharmacology, Kanazawa University, Ishikawa, Japan.
          Article
          10.1002/jlb.56.5.559
          7964163
          12fd7c3c-bd00-46ca-980d-efeabf548b91
          History

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