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      Long-Term Synaptic Plasticity Tunes the Gain of Information Channels through the Cerebellum Granular Layer.

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          Abstract

          A central hypothesis on brain functioning is that long-term potentiation (LTP) and depression (LTD) regulate the signals transfer function by modifying the efficacy of synaptic transmission. In the cerebellum, granule cells have been shown to control the gain of signals transmitted through the mossy fiber pathway by exploiting synaptic inhibition in the glomeruli. However, the way LTP and LTD control signal transformation at the single-cell level in the space, time and frequency domains remains unclear. Here, the impact of LTP and LTD on incoming activity patterns was analyzed by combining patch-clamp recordings in acute cerebellar slices and mathematical modeling. LTP reduced the delay, increased the gain and broadened the frequency bandwidth of mossy fiber burst transmission, while LTD caused opposite changes. These properties, by exploiting NMDA subthreshold integration, emerged from microscopic changes in spike generation in individual granule cells such that LTP anticipated the emission of spikes and increased their number and precision, while LTD sorted the opposite effects. Thus, akin with the expansion recoding process theoretically attributed to the cerebellum granular layer, LTP and LTD could implement selective filtering lines channeling information toward the molecular and Purkinje cell layers for further processing.

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          Author and article information

          Journal
          Biomedicines
          Biomedicines
          MDPI AG
          2227-9059
          2227-9059
          Dec 08 2022
          : 10
          : 12
          Affiliations
          [1 ] Department of Biomedical, Metabolic and Neural Sciences, Via Campi 287, University of Modena and Reggio Emilia, 41125 Modena, Italy.
          [2 ] Centre for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy.
          [3 ] Department of Brain and Behavioral Sciences, Neurophysiology Unit, Via Forlanini 6, 27100 Pavia, Italy.
          [4 ] Brain Connectivity Center (BCC), IRCCS C. Mondino, Via Mondino 2, 27100 Pavia, Italy.
          Article
          biomedicines10123185
          10.3390/biomedicines10123185
          9775043
          36551941
          13161904-6453-4693-8d7c-c1fd35948874
          History

          computational modeling,cerebellum,long-term plasticity,granule cell,gain modulation

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