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      Influence of Various Catatoxic Steroids Upon Chronic Dihydrotachysterol Intoxication

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          Abstract

          In rats, the catabolism normally induced by chronic dihydrotachysterol (DHT) intoxication is counteracted (in approximately decreasing order of activity) by: norbolethone, ethylestrenol, CS-1 and pregnenolone-16α-carbonitrile (PCN). Spironolactone was previously shown to antagonize DHT in acute experiments. However in the chronic experiments reported here, it is inactive in this respect and even abolishes the high anti-DHT of norbolethone and ethylestrenol. Several possible mechanisms are discussed which might explain these antagonisms, for example: (1) Spironolactone may act by accelerating the enzymatic degradation of the protective anabolic steroids. (2) The 2 types of steroids may compete with each other for receptor sites. (3) Spironolactone and the anabolics may exert opposing actions on DHT metabolism.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1971
          1971
          21 November 2008
          : 2
          : 3
          : 129-138
          Affiliations
          Institute of Medicine and Experimental Surgery, University of Montreal, Montreal
          Article
          178229 Hormones 1971;2:129–138
          10.1159/000178229
          © 1971 S. Karger AG, Basel

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          Page count
          Pages: 10
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