There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Snakebite envenoming is a relevant public health problem in French Guiana, and Bothrops
atrox is responsible for the vast majority of envenomings in this overseas French
territory. The preclinical efficacy of freeze-dried antivenoms manufactured in Costa
Rica (Polival-ICP®) and Mexico (Antivipmyn Tri®) was assessed against the lethal,
hemorrhagic, in vitro coagulant, and myotoxic effects of Bothrops atrox venom from
French Guiana. Antivenoms differ in protein concentration and in the type of active
principle (IgG and F (ab')2, respectively). Polival-ICP® showed significantly higher
neutralizing activity against lethal, hemorrhagic and in vitro coagulant activities
of the venom. Antivenoms neutralized myotoxic effect to a similar extent. In the case
of lethal activity, Antivipmyn Tri® did not neutralize the effect at the highest antivenom
level tested (1 mg venom/mL antivenom).