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      Peroxisome proliferator-activated receptors in inflammation control.

      1 , ,
      The Journal of endocrinology

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          Abstract

          Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear receptor superfamily. PPARalpha is highly expressed in liver, skeletal muscle, kidney, heart and the vascular wall. PPARgamma is predominantly detected in adipose tissue, intestine and macrophages. PPARs are activated by fatty-acid derivatives and pharmacological agents such as fibrates and glitazones which are specific for PPARalpha and PPARgamma respectively. PPARs regulate lipid and lipoprotein metabolism, glucose homeostasis, cell proliferation and differentiation, and apoptosis. PPARalpha controls intra- and extracellular lipid metabolisms whereas PPARgamma triggers adipocyte differentiation and promotes lipid storage. In addition, PPARs also modulate the inflammatory response. PPAR activators have been shown to exert anti-inflammatory activities in various cell types by inhibiting the expression of proinflammatory genes such as cytokines, metalloproteases and acute-phase proteins. PPARs negatively regulate the transcription of inflammatory response genes by antagonizing the AP-1, nuclear factor-kappaB (NF-kappaB), signal transducer and activator of transcription and nuclear factor of activated T-cells signalling pathways and by stimulating the catabolism of proinflammatory eicosanoids. These recent findings indicate a modulatory role for PPARs in inflammation with potential therapeutical applications in chronic inflammatory diseases.

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          Author and article information

          Journal
          J. Endocrinol.
          The Journal of endocrinology
          0022-0795
          0022-0795
          Jun 2001
          : 169
          : 3
          Affiliations
          [1 ] U325 INSERM, Département d'Athérosclérose, Institut Pasteur de Lille, 1 rue Professeur Calmette, 59019 Lille, France.
          Article
          JOE04117
          10.1677/joe.0.1690453
          11375115
          136cf6f6-a6bd-43c9-9d82-3b370e543e85
          History

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