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      Electrophysiological Properties of the Mesenteric Artery of the Rabbit with Perinephritis Hypertension


      Journal of Vascular Research

      S. Karger AG

      Membrane potential, Hypertension, Electrophysiology, Mesenteric artery, Perinephritis

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          Membrane potential and tension were simultaneously recorded in ileal arteries isolated from rabbits with perinephritis hypertension and from sham operated controls. Stimulation of perivascular nerves with single pulses produced excitatory junction potentials, action potentials and contraction. Setting resting tension to levels equivalent to intra-luminal pressures of 23, 70 and 114 mm Hg had no effect on the resting membrane potential, excitatory junction potential amplitude, action potential threshold or membrane time constant. The resting membrane potential in arteries from hypertensive rabbits was 3.7 mV less negative than in the shams. There were no significant changes in the action potential threshold or membrane time constant. It is suggested that the changes observed in the membrane potential may contribute to the increased responsiveness found in arteries from this model of hypertension.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 25
          : 4
          : 157-165
          Department of Physiology, Monash University, Clayton, Vic., Australia
          158729 Blood Vessels 1988;25:157–165
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 9
          Research Paper


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