Dynamics of coexisting HCMV-UL97 and UL54 drug-resistance associated mutations in patients after haematopoietic cell transplantation.

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Abstract

Resistance to antiviral drugs can be a severe problem in transplant recipients. Mutations in the HCMV phosphotransferase-gene (UL97) and the polymerase-gene (UL54) are responsible for resistance against ganciclovir (GCV), cidofovir (CDV) and foscarnet (PFA). Most frequently mutations in the UL97-gene are associated with resistance to GCV. Resistance against PFA and CDV is associated to mutations in the UL54-gene. There are only few reports about multidrug-resistance with mutations in both genes in patients after allogeneic haematopoietic cell transplantation (HCT).

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Journal

Journal ID (iso-abbrev): J. Clin. Virol.

Title: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

Publisher: Elsevier BV

ISSN (Electronic): 1873-5967

ISSN (Print): 1386-6532

Publication date (Electronic): May 2013

Volume: 57

Issue: 1

Affiliations

[1 ] Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital of Tübingen, 72076 Tübingen, Germany.

Article

Publisher Item ID: S1386-6532(13)00008-5

DOI: 10.1016/j.jcv.2013.01.003

PubMed ID: 23375740

SO-VID: 138df9c0-60ea-4f9e-9001-6d1150c7e360

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