- Record: found
- Abstract: found
- Article: not found
Identification and characterization of amino-piperidinequinolones and quinazolinones as MCHr1 antagonists.
Christopher Blackburn
1 ,
Matthew J LaMarche ,
James Brown ,
Jennifer Lee Che ,
Courtney A Cullis ,
Sujen Lai ,
Martin Maguire ,
Thomas Marsilje ,
Bradley Geddes ,
Elizabeth Govek ,
Vivek Kadambi ,
Colleen Doherty ,
Brian Dayton ,
Sevan Brodjian ,
Kennan C Marsh ,
Christine A Collins ,
Philip R Kym
May 15 2006
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Several potent, functionally active MCHr1 antagonists derived from quinolin-2(1H)-ones and quinazoline-2(1H)-ones have been synthesized and evaluated. Pyridylmethyl substitution at the quinolone 1-position results in derivatives with low-nM binding potency and good selectivity with respect to hERG binding.