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      Presence of Hormonally-Sensitive Adenylate Cyclase Receptors in Capillary-Enriched Fractions from Rat Cerebral Cortex


      Journal of Vascular Research

      S. Karger AG

      Cerebral capillaries, Catecholamines, Adenylate cyclase, Histamine

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          The 10 000 g particulate fraction from capillary-enriched fractions isolated from rat cerebral cortex was shown to possess an adenylate cyclase highly sensitive to activation by sodium fluoride, norepinephrine, epinephrine, isoproterenol and dopamine. To a lesser extent histamine and three dopamine agonists, namely M-7 (5, 6-dihydroxy-2-dimethylamino tetralin), ET-495 (methane sulfonate of pyribedil), and S-584 (metabolite of pyribedil) stimulated the enzyme preparation. The action of norepinephrine was blocked by propranolol while phenotolamine and haloperidol were relatively ineffective except at highest concentrations. Phentolamine and propranolol at only highest concentrations (10<sup>–4</sup> m) antagonized the action of dopamine. Haloperidol was seen to be a potent inhibitor of either dopamine- or dopamine agonist-sensitive adenylate cyclase. No effects on the enzyme were observed with methoxamine, octopamine or serotonin. These preliminary data suggest the presence of a mixed population of receptors for adenylate cyclase in rat brain capillaries.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 15
          : 5
          : 286-298
          Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Ala. and Department of Pharmacology, School of Medicine, University of New Mexico, Albuquerque, N.Mex.
          158174 Blood Vessels 1978;15:286–298
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 13


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