4
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Development and characterization of nano-fiber patch for the treatment of glaucoma.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate and dorzolamide hydrochloride as model drugs. The nano-fibers were prepared by electrospinning technique and were characterized on the basis of fiber diameter, morphology, entrapment efficiency, mucoadhesive strength, and drug release behavior, etc. Final formulations were inserted in the cul-de-sac of glaucoma induced rabbits and the efficacy of the formulation was evaluated. The results clearly indicated the potential of the developed formulation for occur drug delivery. There was a significant fall in the intraocular pressure compared to commercial eye drops.

          Related collections

          Author and article information

          Journal
          Eur J Pharm Sci
          European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
          1879-0720
          0928-0987
          Mar 12 2014
          : 53
          Affiliations
          [1 ] Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India.
          [2 ] Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India. Electronic address: amitkumargoyal1979@gmail.com.
          Article
          S0928-0987(13)00455-7
          10.1016/j.ejps.2013.11.016
          24333373
          Copyright © 2013 Elsevier B.V. All rights reserved.

          Comments

          Comment on this article