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      Micropuncture Study of the Action of Angiotensin-II on Tubular Sodium and Water Reabsorption in the Rat

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      Nephron

      S. Karger AG

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          Abstract

          The effect of val-äangiotensin-II-amide on tubular sodium and water reabsorption in the rat kidney was studied by micropuncture techniques. An angiotensin infusion of 0.2–0.5 µg/min/kg caused a significant increase ( + 16 mEq/l) in the sodium concentration of tubular fluid collected from the distal tubule, as compared to collections made from the same site of the tubule during saline infusion alone. TF/P-inulin ratio remained unchanged. Glomerular filtration rate, sodium and water excretion were unaltered. During an angiotensin infusion of 1.0-1.5 µg/min/kg a similar elevation of the distal tubular sodium concentration was observed, but TF/P-inulin ratio decreased significantly. Urinary water and sodium excretion increased. An elevation of the intratubular concentration of angiotensin to 2.5 µg/ml had no effect upon tubular reabsorptive capacity, as measured by the ‘split oil-droplet method’ in the proximal or in the distal tubule. Direct application of angiotensin from the capillary side of the tubule by peritubular perfusion did not alter ‘reabsorptive half-time’ in the proximal tubule, but caused a significant prolongation of ‘reabsorptive half-time’ in the distal tubule from 35.6–67.7 sec. These results demonstrate that angiotensin, offered from the capillary side of the tubule, directly inhibits sodium reabsorption in the distal tubule.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-0996-1
          978-3-318-02134-9
          1660-8151
          2235-3186
          1969
          1969
          26 November 2008
          : 6
          : 3
          : 173-187
          Affiliations
          Max-Planck-Institut für experimentelle Medizin, Abteilung Physiologie, Göttingen
          Article
          179727 Nephron 1969;6:173–187
          10.1159/000179727
          4307191
          © 1969 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 15
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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