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      Evaluation of Lidoflazine as an Anti-Anginal Drug

      ,

      Cardiology

      S. Karger AG

      Exercise tests, Angina pectoris, Double blind trial

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          Abstract

          In a double-blind controlled trial, lidoflazine (in a daily oral dose of 240 mg for three periods of 8 weeks each) was compared to an inert preparation. 20 of 27 patients completed the double blind study. 4 patients were withdrawn from the study for unrelieved angina. Three of these patients were on the placebo and failed to respond to treatment with the active drug. As assessed by the frequency of anginal pains, nitroglycerine consumption, the anginal threshold and the extent of exercise-induced ST segment depression, lidoflazine was not found superior to the placebo. The heart rates on exercise were, however, lower after lidoflazine administration. The significance of this observation remains unexplained.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1973
          1973
          29 October 2008
          : 58
          : 4
          : 209-219
          Affiliations
          Cardiac Laboratory, Royal Melbourne Hospital (Director: J. G. Sloman), Melbourne
          Article
          169636 Cardiology 1973;58:209–219
          10.1159/000169636
          4206284
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Paper

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