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      Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007

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          Abstract

          One-sentence summary for table of contents: The full coding region nucleic acid sequence and serologic properties of the virus were identified.

          Abstract

          Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda from a sentinel monkey in 1947. Mosquito and sentinel animal surveillance studies have demonstrated that ZIKV is endemic to Africa and Southeast Asia, yet reported human cases are rare, with <10 cases reported in the literature. In June 2007, an epidemic of fever and rash associated with ZIKV was detected in Yap State, Federated States of Micronesia. We report the genetic and serologic properties of the ZIKV associated with this epidemic.

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          Most cited references 20

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          Zika virus. I. Isolations and serological specificity.

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            Phylogeny of the genus Flavivirus.

            We undertook a comprehensive phylogenetic study to establish the genetic relationship among the viruses of the genus Flavivirus and to compare the classification based on molecular phylogeny with the existing serologic method. By using a combination of quantitative definitions (bootstrap support level and the pairwise nucleotide sequence identity), the viruses could be classified into clusters, clades, and species. Our phylogenetic study revealed for the first time that from the putative ancestor two branches, non-vector and vector-borne virus clusters, evolved and from the latter cluster emerged tick-borne and mosquito-borne virus clusters. Provided that the theory of arthropod association being an acquired trait was correct, pairwise nucleotide sequence identity among these three clusters provided supporting data for a possibility that the non-vector cluster evolved first, followed by the separation of tick-borne and mosquito-borne virus clusters in that order. Clades established in our study correlated significantly with existing antigenic complexes. We also resolved many of the past taxonomic problems by establishing phylogenetic relationships of the antigenically unclassified viruses with the well-established viruses and by identifying synonymous viruses.
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              Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia.

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                Author and article information

                Journal
                Emerg Infect Dis
                EID
                Emerging Infectious Diseases
                Centers for Disease Control and Prevention
                1080-6040
                1080-6059
                August 2008
                : 14
                : 8
                : 1232-1239
                Affiliations
                [* ]Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
                Author notes
                Address for correspondence: Robert S. Lanciotti, Diagnostic and Reference Laboratory, Arbovirus Diseases Branch, Centers for Disease Control and Prevention, 3150 Rampart Rd, CSU Foothills Campus, Fort Collins, CO 80521, USA; email: rsl2@ 123456cdc.gov
                08-0287
                10.3201/eid1408.080287
                2600394
                18680646
                Categories
                Research

                Infectious disease & Microbiology

                laboratory diagnosis, flavivirus, research, serology, rt-pcr, zika virus

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