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      • Record: found
      • Abstract: found
      • Article: found

      Chemical Modification Studies on Purified Bovine Lens Aldose Reductase

      research-article
      Author(s): , ,
      Publication date (Electronic):
      Journal: Ophthalmic Research
      Publisher: S. Karger AG
      Keywords: Aldose, Reductase, NADPH, Autozidation, Diabetes

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          Abstract

          Chemical modification studies on homogeneous bovine lens aldose reductase using diethylpyrocarbonate, phenylglyoxal, butanedione, N-ethylmaleimide and p-chloromercuribenzoate indicate that histidine and arginine residues located at or near the nucleotide binding site may be important in binding or orientation of the NADPH, and that NADPH oxidation with glucose requires protein thiol.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1985
          Publication date (Print): 1985
          Publication date (Electronic): 04 December 2009
          Volume: 17
          Issue: 3
          Pages: 185-188
          Affiliations
          Nuffield Laboratory of Ophthalmology, University of Oxford, UK
          Article
          Publisher ID: 265372 Other ID: Ophthalmic Res 1985;17:185–188
          DOI: 10.1159/000265372
          PubMed ID: 3925401
          SO-VID: 13e0295e-9526-4626-9388-7769d017605b
          Copyright © © 1985 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 13 February 1984
          Date accepted : 09 July 1984
          Page count
          Pages: 4
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Reductase,Aldose,NADPH,Autozidation,Diabetes
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Reductase, Aldose, NADPH, Autozidation, Diabetes

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