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      Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis.

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          Abstract

          Exosomes are naturally occurring biological nanovesicles utilized by tumors to communicate signals to local and remote cells and tissues. Melanoma exosomes can incite a proangiogenic signaling program capable of remodeling tissue matrices. In this study, we show exosome-mediated conditioning of lymph nodes and define microanatomic responses that license metastasis of melanoma cells. Homing of melanoma exosomes to sentinel lymph nodes imposes synchronized molecular signals that effect melanoma cell recruitment, extracellular matrix deposition, and vascular proliferation in the lymph nodes. Our findings highlight the pathophysiologic role and mechanisms of an exosome-mediated process of microanatomic niche preparation that facilitates lymphatic metastasis by cancer cells.

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          Author and article information

          Journal
          Cancer Res
          Cancer research
          American Association for Cancer Research (AACR)
          1538-7445
          0008-5472
          Jun 01 2011
          : 71
          : 11
          Affiliations
          [1 ] Consortium for Translational Research in Advanced Imaging and Nanomedicine, Washington University School of Medicine, St. Louis, Missouri, USA. jhood@dom.wustl.edu
          Article
          0008-5472.CAN-10-4455
          10.1158/0008-5472.CAN-10-4455
          21478294
          13e16da4-fa2d-4b1e-ab6c-05001470e149
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