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      Specific α-Adrenergic Receptor Desensitization in Vascular Smooth Muscle

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          Abstract

          Specific desensitization of vascular tissue to norepinephrine was studied using an open-ring-type strip preparation of rabbit aorta. Aortae were taken from untreated, reserpine-pretreated (0.1 mg/kg/day; 3, 5, or 7 days) and 6-hydroxydopamine-pretreated (50 mg/kg; 3 or 7 days before sacrifice) rabbits. Aortic strips from the pretreated rabbits were supersensitive to norepinephrine. Subsequent to obtaining the first dose-response curve for norepinephrine, aortic strips were less sensitive to norepinephrine. It was found that desensitization to norepinephrine occurred following 10 min preincubation with 10<sup>–6</sup> m norepinephrine, and 20 min preincubation with 10<sup>–7</sup> m norepinephrine. The desensitization of supersensitive strips was significantly greater than in controls. Dopamine and isoproterenol desensitized both untreated and pretreated strips to norepinephrine. Phenylephrine desensitized strips to norepinephrine from 6-hydroxydopamine-pretreated rabbits. Acetylcholine and potassium did not desensitize strips to norepinephrine; however, acetylcholine desensitized strips to acetylcholine. It is concluded from these studies that norepinephrine desensitization is a specific α-adrenergic-related event.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1978
          1978
          18 September 2008
          : 15
          : 4
          : 247-258
          Affiliations
          Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Tex., and Institut für Pharmakologie, Christian-Albrechts-Universität, Kiel
          Article
          158170 Blood Vessels 1978;15:247–258
          10.1159/000158170
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 12
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