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      Influence of sympathetic nerve activity on aortic hemodynamics and pulse wave velocity in women

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          Abstract

          Autonomic ganglionic blockade results in significant decreases in multiple aortic pulse wave characteristics (e.g., augmented pressure) and central pulse wave velocity in older postmenopausal women but not in young premenopausal women. Certain aortic pulse wave parameters are negatively influenced by sympathetic activity to a greater extent in older postmenopausal women.

          Abstract

          Central (aortic) blood pressure, arterial stiffness, and sympathetic nerve activity increase with age in women. However, it is unknown if the age-related increase in sympathetic activity influences aortic hemodynamics and carotid-femoral pulse wave velocity (cfPWV), an index of central aortic stiffness. The goal of this study was to determine if aortic hemodynamics and cfPWV are directly influenced by sympathetic nerve activity by measuring aortic hemodynamics, cfPWV, and muscle sympathetic nerve activity (MSNA) in women before and during autonomic ganglionic blockade with trimethaphan camsylate. We studied 12 young premenopausal (23 ± 4 yr) and 12 older postmenopausal (57 ± 3 yr) women. These women did not differ in body mass index or mean arterial pressure ( P > 0.05 for both). At baseline, postmenopausal women had higher aortic pulse pressure, augmented pressure, augmentation index adjusted for a heart rate of 75 beats/min, wasted left ventricular pressure energy, and cfPWV than young women ( P < 0.05). During ganglionic blockade, postmenopausal women had a greater decrease in these variables in comparison to young women ( P < 0.05). Additionally, baseline MSNA was negatively correlated with the reductions in aortic pulse pressure, augmented pressure, and wasted left ventricular pressure energy during ganglionic blockade in postmenopausal women ( P < 0.05) but not young women. Baseline MSNA was not correlated with the changes in augmentation index adjusted for a heart rate of 75 beats/min or cfPWV in either group ( P > 0.05 for all). Our results suggest that some aortic hemodynamic parameters are influenced by sympathetic activity to a greater extent in older postmenopausal women than in young premenopausal women.

          NEW & NOTEWORTHY Autonomic ganglionic blockade results in significant decreases in multiple aortic pulse wave characteristics (e.g., augmented pressure) and central pulse wave velocity in older postmenopausal women but not in young premenopausal women. Certain aortic pulse wave parameters are negatively influenced by sympathetic activity to a greater extent in older postmenopausal women.

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          Author and article information

          Journal
          Am J Physiol Heart Circ Physiol
          Am. J. Physiol. Heart Circ. Physiol
          ajpheart
          ajpheart
          AJPHEART
          American Journal of Physiology - Heart and Circulatory Physiology
          American Physiological Society (Bethesda, MD )
          0363-6135
          1522-1539
          1 February 2017
          6 December 2016
          1 February 2018
          : 312
          : 2
          : H340-H346
          Affiliations
          [1] 1Mayo Clinic College of Medicine, Mayo Clinic , Rochester, Minnesota;
          [2] 2Department of Kinesiology, University of Wisconsin-Madison , Madison, Wisconsin;
          [3] 3 University of Bristol , Bristol, United Kingdom;
          [4] 4Department of Anesthesiology, Mayo Clinic , Rochester, Minnesota; and
          [5] 5Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa , Iowa City, Iowa
          Author notes
          Address for reprint requests and other correspondence: D. P. Casey, Dept. of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 (e-mail: darren-casey@ 123456uiowa.edu ).
          Article
          PMC5336574 PMC5336574 5336574 H-00447-2016 H-00447-2016
          10.1152/ajpheart.00447.2016
          5336574
          27923789
          140b4405-87f3-4ba8-8605-bb3458e3939c
          Copyright © 2017 the American Physiological Society
          History
          : 22 June 2016
          : 14 November 2016
          : 29 November 2016
          Funding
          Funded by: http://doi.org/10.13039/100006108 HHS | NIH | National Center for Advancing Translational Sciences (NCATS)
          Award ID: RR024150
          Funded by: http://doi.org/10.13039/100000002 HHS | National Institutes of Health (NIH)
          Award ID: AG038067
          Award ID: AR056950
          Award ID: HL083947
          Award ID: HL105467
          Funded by: http://doi.org/10.13039/100000968 American Heart Association (AHA)
          Award ID: 2170087
          Categories
          Research Article
          Integrative Cardiovascular Physiology and Pathophysiology

          arterial stiffness,central hemodynamics,autonomic nervous system,aging,menopause

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