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      Iodine-Induced Hypothyroidism in Patients on Regular Dialysis Treatment

      a , b , a


      S. Karger AG

      Iodine-induced hypothyroidism, Regular dialysis

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          Hypothyroidism with a serum concentration of thyroid-stimulating hormone (TSH) above 40 μU/ml was noted in 3 (3.2%) of 93 patients on regular hemodialysis or continuous ambulatory peritoneal dialysis. These 3 patients had no history of thyroid disease and were receiving no medication known to influence thyroid function. They had habitually eaten iodine-rich foods and showed an enlarged thyroid gland with a preserved radioactive iodine uptake and a markedly elevated serum inorganic iodine (II) level. In all 3 patients, both thyroidal microsomal antibody and thyroglobulin antibody titers measured by hemagglutination methods were less than 100, and TSH-binding inhibitory immunoglobulin was negative. Moreover, histologically no lymphocytic infiltrations were observed. With only iodine restriction, serum TSH level markedly decreased from 44.6 to 3.6 μU/ml in case 1, from 90.6 to 3.2 μU/ml in case 2 and from 43.2 to 9.4 μU/ml in case 3 in parallel with decreases in the serum II level. These results suggest that at least in an area like Japan, where the daily intake of iodine is high, iodine-induced hypothyroidism may be induced in patients undergoing regular dialysis treatment even in the absence of apparent underlying thyroid disease.

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          Author and article information

          S. Karger AG
          12 December 2008
          : 65
          : 1
          : 51-55
          aInternal Medicine, Kurobe City Hospital, Kurobe, Toyama; bDepartment of Nuclear Medicine, School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
          187440 Nephron 1993;65:51–55
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 5
          Original Paper

          Cardiovascular Medicine, Nephrology

          Iodine-induced hypothyroidism, Regular dialysis


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