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      Heterotopic Ossification: Basic-Science Principles and Clinical Correlates

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Update

          This article was updated on July 22, 2015, because the name of one of the authors, Victor W. Wong, was listed incorrectly. The name, which previously read “Victor C. Wong,” on pages 1101 and 1108, now reads “Victor W. Wong.”

          An erratum has been published: J Bone Joint Surg Am. 2015 Sep 2;97(17):e59.

          ➤ Heterotopic ossification occurs most commonly after joint arthroplasty, spinal cord injury, traumatic brain injury, blast trauma, elbow and acetabular fractures, and thermal injury.

          ➤ The conversion of progenitor cells to osteogenic precursor cells as a result of cell-mediated interactions with the local tissue environment is affected by oxygen tension, pH, availability of micronutrients, and mechanical stimuli, and leads to heterotopic ossification.

          ➤ Radiation and certain nonsteroidal anti-inflammatory medications are important methods of prophylaxis against heterotopic ossification.

          ➤ Well-planned surgical excision can improve patient outcomes regardless of the joint involved or the initial cause of injury.

          ➤ Future therapeutic strategies are focused on targeted inhibition of local factors and signaling pathways that catalyze ectopic bone formation.

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          Author and article information

          Journal
          J Bone Joint Surg Am
          J Bone Joint Surg Am
          jbjsam
          jbjsam
          The Journal of Bone and Joint Surgery. American Volume
          The Journal of Bone and Joint Surgery, Inc.
          0021-9355
          1535-1386
          1 July 2015
          01 July 2015
          : 97
          : 13
          : 1101-1111
          Affiliations
          [1 ]Department of Surgery, University of Michigan Health Systems, 1500 East Medical Center Drive, Taubman Center, XPC 5340, Ann Arbor, MI 48109-0219. E-mail address for B. Levi: blevi@ 123456umich.edu
          [2 ]Department of Surgery, Johns Hopkins School of Medicine, 4924 Campbell Boulevard, Baltimore, MD 21236
          [3 ]Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD 20910
          [4 ]Department of Pathology & Laboratory Medicine, University of California at Los Angeles, DGSOM, 200 Medical Plaza, Los Angeles, CA 90095
          Article
          PMC6948799 PMC6948799 6948799 jbjsam.n01056
          10.2106/JBJS.N.01056
          6948799
          26135077
          141df80e-74b3-4742-8df2-dcaf2426fba6
          Copyright © 2015 by The Journal of Bone and Joint Surgery, Incorporated
          History
          Page count
          Pages: 11
          Categories
          0010
          0170
          0070
          Current Concepts Review
          Custom metadata
          Peer Review: This article was reviewed by the Editor-in-Chief and one Deputy Editor, and it underwent blinded review by two or more outside experts. The Deputy Editor reviewed each revision of the article, and it underwent a final review by the Editor-in-Chief prior to publication. Final corrections and clarifications occurred during one or more exchanges between the author(s) and copyeditors.

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