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      Tear Volume in Early and Late Phases of Ocular Anaphylaxis in Guinea Pigs

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          Abstract

          Three models of ocular anaphylaxis containing 6 guinea pigs each were used to examine their effect on tear volume. In the first model, IgGl-rich anti-dinitrophenol (DNP) bovine γ-globulin serum was injected subconjunctivally, and the animals were challenged 4 h later with topically applied di-DNP-lysine. In the second model, IgE-rich anti-egg albumin serum was injected subconjunctivally, and the animals were challenged 8 days later with topical instillation of egg albumin. In the third model, IgE-rich anti-egg albumin serum was injected intravenously, and animals were challenged 8 days later with topically applied egg albumin. Tears were collected before the procedure, 0.5 h after anaphylaxis was initiated, and then hourly for 8, 10, 12, 24, and 48 h after challenge. All animal eyes undergoing ocular anaphylaxis had significantly increased tearing. Tear volumes remained elevated in the first model beyond the observation period of 48 h.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1991
          1991
          10 December 2009
          : 23
          : 6
          : 335-341
          Affiliations
          aEye Research Institute, and bDepartment of Ophthalmology, Harvard Medical School, Boston, Mass., USA
          Article
          267131 Ophthalmic Res 1991;23:335–341
          10.1159/000267131
          1803315
          1433808b-8b70-4255-a485-c9d2ddcdd076
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 08 February 1990
          : 15 July 1991
          Page count
          Pages: 7
          Categories
          Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Tears,Animal model,Late-phase reaction,Allergy,Homocytotropic antibody,Early-phase reaction,Immunoglobulin,Anaphylaxis

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