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      Effects of Bromocriptine and Ectopic Pituitary Transplants on Pituitary and Hypothalamic Nuclear Androgen Receptors in the Male Hamster

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          Abstract

          Nuclear androgen receptors (Arn)were measured in the pituitaries and hypothalami of adult male golden hamsters which had been injected with a long-acting preparation of bromocriptine or had pituitaries from adult females transplanted under the renal capsules. Treatment with bromocriptine markedly reduced pituitary Arn and plasma prolactin levels without altering plasma testosterone levels or hypothalamic Ar <sub>N</sub>. Ectopic pituitary transplants did not affect Arn in either the pituitary or the hypothalamus. These findings suggest that normal rates of prolactin synthesis and/or secretion may be required for maintenance of Arn in the pituitary of adult male hamsters.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1988
          1988
          02 April 2008
          : 47
          : 3
          : 236-240
          Affiliations
          aDepartment of Obstetrics and Gynecology, Michael Reese Medical Center, Pritzker School of Medicine, University of Chicago, Ill.; bDepartment of Physiology, School of Medicine, Southern Illinois University, Carbondale, Ill., USA
          Article
          124917 Neuroendocrinology 1988;47:236–240
          10.1159/000124917
          3362305
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 5
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          Original Paper

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