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      Effects of Bromocriptine and Ectopic Pituitary Transplants on Pituitary and Hypothalamic Nuclear Androgen Receptors in the Male Hamster

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          Abstract

          Nuclear androgen receptors (Arn)were measured in the pituitaries and hypothalami of adult male golden hamsters which had been injected with a long-acting preparation of bromocriptine or had pituitaries from adult females transplanted under the renal capsules. Treatment with bromocriptine markedly reduced pituitary Arn and plasma prolactin levels without altering plasma testosterone levels or hypothalamic Ar <sub>N</sub>. Ectopic pituitary transplants did not affect Arn in either the pituitary or the hypothalamus. These findings suggest that normal rates of prolactin synthesis and/or secretion may be required for maintenance of Arn in the pituitary of adult male hamsters.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1988
          1988
          02 April 2008
          : 47
          : 3
          : 236-240
          Affiliations
          aDepartment of Obstetrics and Gynecology, Michael Reese Medical Center, Pritzker School of Medicine, University of Chicago, Ill.; bDepartment of Physiology, School of Medicine, Southern Illinois University, Carbondale, Ill., USA
          Article
          124917 Neuroendocrinology 1988;47:236–240
          10.1159/000124917
          3362305
          145b05fc-06c0-4733-9bf1-692f648af5a4
          © 1988 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 19 May 1987
          : 14 August 1987
          Page count
          Pages: 5
          Categories
          Original Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Bromocriptine,Androgen receptors,Hypothalamus,Prolactin

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