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      Assessment of Left Ventricular Dysfunction in Acromegalic Patients Using Radionuclide Ventriculography Parameters

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          Abstract

          The left ventricular function of 14 acromegalic patients was investigated using radionuclide ventriculography. After labeling the red blood cells with 750-1,000 MBq <sup>99m</sup>Tc-pertechnetate, ECG-triggered left anterior oblique images were recorded. Fourier analysis was then performed on the time-activity curve of the left ventricle. The ejection fraction (EF), peak ejection rate, time to peak ejection (TPE), time to endsystole (TES), peak filling rate (PFR), time to peak filling (TPF), 1/3 EF, 1/3 filling fraction (FF), TPE/T, TPF/T and TES/T values (T: time interval for one heart beat) were calculated for each patient. Five patients (35.7%) had clinical cardiovascular symptoms. A decreased EF was observed in 28.5% of the patients. In comparison to the control group, the EF (53.5 ± 5.5 vs. 60.8 ± 5%p < 0.009), 1/3 EF(14.45 ± 3vs.20 ± 4%, p < 0.001), 1/3 FF (28.5 ± 10.6 vs. 41 ± 11%, p < 0.02), TPE (158 ± 33 vs. 132 ± 35 msp < 0.01), TPE/T (20.2 ± 5 vs. 16 ± 3.7, p < 0.01) and PFR (2.4 ± 0.5 vs. 2.9 ± 0.4 EDC/s, p < 0.005) were significantly different. It was found that TPE was prolonged and the early ejection function was decreased. Diastolic dysfunction was found in 5 (35.7%) patients; 21.4% of the patients had decreased PFR values although they had no cardiac symptom, hypertension and/or cardiomegaly. Scintigraphic parameters did not correlate with the presence of hypertension, cardiomegaly or cardiovascular symptoms. In summary, using radionuclide ventriculography parameters, systolic and diastolic dysfunction were observed in 28.5 and 35.7% of acromegalic patients, respectively.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1992
          1992
          12 November 2008
          : 80
          : 3-4
          : 172-179
          Affiliations
          Hacettepe University, Faculty of Medicine, Departments of aEndocrinology and bNuclear Medicine, Sihhiye-Ankara, Turkey
          Article
          175000 Cardiology 1992;80:172–179
          10.1159/000175000
          1324800
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          General Cardiology

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