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      Sex Hormone-Binding Globulin: Gene Organization and Structure/Function Analyses

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          Human plasma sex hormone-binding globulin (SHBG) and testicular androgen-binding protein (ABP) are homodimeric glycoproteins with a single steroid-binding site. They share the same primary structure and differ only with respect to the types of oligosaccharides attached to them. Both are products of a single gene ( Shbg), the expression of which has been detected in several tissues including liver, testis, placenta, brain and endometrium. The transcript encoding SHBG in hepatocytes and ABP in Sertoli cells is identical. Several other transcripts result from differential exon utilization in sex steroid-responsive tissues, but their biological significance remains obscure. Wild-type and mutant forms of human SHBG have been produced in mammalian cells and Escherichia coli, and have provided insight into the structural and functional properties of SHBG and its related gene products.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          09 December 2008
          : 45
          : 3-5
          : 197-201
          MRC Group in Fetal and Neonatal Health and Development and Departments of Obstetrics and Gynecology, Oncology and Biochemistry, The University of Western Ontario, London, Ont., Canada
          184787 Horm Res 1996;45:197–201
          © 1996 S. Karger AG, Basel

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          Page count
          Pages: 5
          Hormone Binding Proteins: Physiology and Clinical Implications


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