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      Silk Fibroin Based Porous Materials

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          Abstract

          Silk from the Bombyx mori silkworm is a protein-based fiber. Bombyx mori silk fibroin (SF) is one of the most important candidates for biomedical porous material based on its superior machinability, biocompatibility, biodegradation, bioresorbability, and so on. In this paper, we have reviewed the key features of SF. Moreover we have focused on the morphous, technical processing, and biocompatibility of SF porous materials, followed by the application research. Finally, we provide a perspective the potential and problems of SF porous materials.

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          Most cited references138

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          Nanometre diameter fibres of polymer, produced by electrospinning

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            Silk as a Biomaterial.

            Silks are fibrous proteins with remarkable mechanical properties produced in fiber form by silkworms and spiders. Silk fibers in the form of sutures have been used for centuries. Recently regenerated silk solutions have been used to form a variety of biomaterials, such as gels, sponges and films, for medical applications. Silks can be chemically modified through amino acid side chains to alter surface properties or to immobilize cellular growth factors. Molecular engineering of silk sequences has been used to modify silks with specific features, such as cell recognition or mineralization. The degradability of silk biomaterials can be related to the mode of processing and the corresponding content of beta sheet crystallinity. Several primary cells and cell lines have been successfully grown on different silk biomaterials to demonstrate a range of biological outcomes. Silk biomaterials are biocompatible when studied in vitro and in vivo. Silk scaffolds have been successfully used in wound healing and in tissue engineering of bone, cartilage, tendon and ligament tissues.
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              Tissue engineering.

              The loss or failure of an organ or tissue is one of the most frequent, devastating, and costly problems in human health care. A new field, tissue engineering, applies the principles of biology and engineering to the development of functional substitutes for damaged tissue. This article discusses the foundations and challenges of this interdisciplinary field and its attempts to provide solutions to tissue creation and repair.
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                Author and article information

                Journal
                Materials (Basel)
                Materials (Basel)
                materials
                Materials
                Molecular Diversity Preservation International (MDPI)
                1996-1944
                09 December 2009
                December 2009
                : 2
                : 4
                : 2276-2295
                Affiliations
                National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, No. 199 Ren’ai Road, Industrial Park, Suzhou 215123, China; E-Mails: zhangq12041008@ 123456163.com (Q.Z.); ysq_zq@ 123456163.com (S.Y.)
                Author notes
                [* ]Author to whom correspondence should be addressed; E-Mail: mzli@ 123456suda.edu.cn ; Tel.: +86-512-6706-1150; Fax: +86-512-6724-6786.
                Article
                materials-02-02276
                10.3390/ma2042276
                5513580
                1463dbd7-08ba-41fa-8f7b-43c06fe4b026
                © 2009 by the authors.

                Licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

                History
                : 28 October 2009
                : 01 December 2009
                : 07 December 2009
                Categories
                Review

                bombyx mori silk fibroin,porous materials,processing,application

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