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      Regulation of force in vascular smooth muscle

      Journal of Molecular and Cellular Cardiology
      Elsevier BV

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          Abstract

          Vascular smooth muscle contraction plays a defining role in the regulation and maintenance of blood pressure, and its deregulation is associated with many clinical syndromes including hypertension, coronary vasospasm and congestive heart failure. Over the past 20 years, there has been a growing understanding of the regulation of 20 kDa myosin light chain phosphorylation by myosin light chain kinase and myosin light chain phosphatase, the role of splice-variant isoforms of both the myosin heavy chain and the essential myosin light chain, as well as the signaling pathways involved in smooth muscle contraction under normal and pathophysiological conditions. This review will attempt to recapitulate the data in the field, primarily focusing on the contractile response of smooth muscle, and the molecular determinants responsible for the regulation of vascular tone.

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          Author and article information

          Journal
          Journal of Molecular and Cellular Cardiology
          Journal of Molecular and Cellular Cardiology
          Elsevier BV
          00222828
          April 2003
          April 2003
          : 35
          : 4
          : 347-355
          Article
          10.1016/S0022-2828(03)00045-2
          12689814
          147c47f0-36d0-4698-ac7e-129201f3fe5f
          © 2003

          https://www.elsevier.com/tdm/userlicense/1.0/

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