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      Experiencia con el tratamiento endovascular de los aneurismas del tope de la arteria basilar

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          Abstract

          Objetivo. Describir los resultados inmediatos obtenidos en una serie de pacientes con aneurismas del tope de la arteria basilar tratados por vía endovascular en relación con el tamaño del cuello y saco del aneurisma, la presencia o no de ruptura aneurismática y la gravedad clínica. Método. Se realizó un estudio descriptivo en una cohorte retrospectiva de 37 pacientes adultos de ambos sexos con aneurismas del tope de la basilar tratados por vía endovascular (periodo 1993 - 2006). Los pacientes fueron clasificados con la escala de Hunt-Hess. Los aneurismas fueron clasificados según su tamaño y ancho del cuello. El grado de oclusión se clasificó en 4 categorías: A (100%), B (>95%), C (>90%) y D (<90%). Resultados. En el 68% se logró una oclusión grado A y en el 18% se logró una oclusión grado B. La morbilidad fue del 7% en el subgrupo sin HSA y del 28% en el subgrupo con HSA. Se encontró una morbilidad del 9% en el grado HH 0; 12.5% en el grado HH 1-2; 58% en el grado HH 3 y 50% en el grado HH 4-5. La oclusión fue grado A en el 75% de los aneurismas con saco pequeño y cuello angosto y en el 55% de los aneurismas con saco grande y cuello ancho. La morbilidad global fue del 24% y la mortalidad global fue del 5.4%. Conclusión. En base a los resultados descriptos la vía endovascular fue una buena alternativa para el tratamiento en agudo de los aneurismas rotos e incidentales del tope de la basilar, sobre todo cuando tenían un saco pequeño y cuello angosto y presentaban una menor gravedad clínica.

          Translated abstract

          Objective: We describe the early results obtained in a series of cases with basilar tip aneurysms treated by endovascular surgery with detachable coils. The results are compared according to the size of the neck and the sac of the aneurysm, the history of aneurysm rupture and neurological state. Method: A retrospective descriptive study was made in a cohort of 37 adults patients of both sexes with basilar tip aneurysms treated by endovascular surgery (period 1993 - 2006). Hunt- Hess scale was used for patients classification. The aneurysms were classified according to their size and the wide of the neck . The occlusion grade was classified in 4 categories: A (100%), B (> 95%), C (> 90%) and D(<90%). Results: Occlusion grade A was obtained in 68% of patients and occlusion grade B was obtained in 18% of patients.The morbidity was 7% in the non-SHA group and 28% in the SAH group. Morbidity was 9% in HH 0, 12.5% in grade HH 1-2, 58% in grade HH 3 and 50% in grade HH 4-5. Occlusion was grade A in 75% of the aneurysms with small sac and narrow neck and in the 55% of the aneurysms with a huge sac and broad neck. Global morbidity was 24% and global mortality was 5.4% Conclusion: According with our results, endovascular surgery was a good alternative for acute ruptured basilar tip aneurysms and incidental ones too, mainly when they had smaller sacs, narrower necks and a better neurological state.

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          International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial.

          Endovascular detachable coil treatment is being increasingly used as an alternative to craniotomy and clipping for some ruptured intracranial aneurysms, although the relative benefits of these two approaches have yet to be established. We undertook a randomised, multicentre trial to compare the safety and efficacy of endovascular coiling with standard neurosurgical clipping for such aneurysms judged to be suitable for both treatments. We enrolled 2143 patients with ruptured intracranial aneurysms and randomly assigned them to neurosurgical clipping (n=1070) or endovascular treatment by detachable platinum coils (n=1073). Clinical outcomes were assessed at 2 months and at 1 year with interim ascertainment of rebleeds and death. The primary outcome was the proportion of patients with a modified Rankin scale score of 3-6 (dependency or death) at 1 year. Trial recruitment was stopped by the steering committee after a planned interim analysis. Analysis was per protocol. 190 of 801 (23.7%) patients allocated endovascular treatment were dependent or dead at 1 year compared with 243 of 793 (30.6%) allocated neurosurgical treatment (p=0.0019). The relative and absolute risk reductions in dependency or death after allocation to an endovascular versus neurosurgical treatment were 22.6% (95% CI 8.9-34.2) and 6.9% (2.5-11.3), respectively. The risk of rebleeding from the ruptured aneurysm after 1 year was two per 1276 and zero per 1081 patient-years for patients allocated endovascular and neurosurgical treatment, respectively. In patients with a ruptured intracranial aneurysm, for which endovascular coiling and neurosurgical clipping are therapeutic options, the outcome in terms of survival free of disability at 1 year is significantly better with endovascular coiling. The data available to date suggest that the long-term risks of further bleeding from the treated aneurysm are low with either therapy, although somewhat more frequent with endovascular coiling.
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            Case-fatality rates and functional outcome after subarachnoid hemorrhage: a systematic review.

            During the last three decades, new management strategies have been developed for patients with aneurysmal subarachnoid hemorrhage. To assess whether the case-fatality rate has improved after the introduction of new management strategies, we studied outcome in all population-based studies from 1960 onward. To identify population-based studies that reported on case-fatality rate in subarachnoid hemorrhage, we performed a MEDLINE search and checked all reference lists of the studies found. Two authors (J.W.H. and G.J.E.R.) independently assessed all studies for eligibility, using predefined criteria for case finding and diagnosis, and extracted data on case-fatality rates. We used weighted linear regression analysis to quantify change in case-fatality rate over time. We found 21 studies, describing 25 study periods between 1960 and 1992. Case-fatality rates varied between 32% and 67%, with the exception of one recent study. The case-fatality rate decreased by 0.5% per year (95% confidence interval, -0.1 to 1.2); the decline was steeper after adjustment for age and sex (0.9% per year; 95% confidence interval, -0.7 to 2.6; data from 12 studies). The case-fatality rate after subarachnoid hemorrhage has decreased during the last three decades. A plausible explanation for this decrease is the improved management of patients with subarachnoid hemorrhage.
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              • Article: not found

              International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomized trial.

              Endovascular detachable coil treatment is being increasingly used as an alternative to craniotomy and clipping for some ruptured intracranial aneurysms, although the relative benefits of these two approaches have yet to be established. We undertook a randomized, multicenter trial to compare the safety and efficacy of endovascular coiling with standard neurosurgical clipping for such aneurysms judged to be suitable for both treatments. We enrolled 2143 patients with ruptured intracranial aneurysms and randomly assigned them to neurosurgical clipping (n = 1070) or endovascular treatment by detachable platinum coils (n = 1073). Clinical outcomes were assessed at both 2 months and at 1 year with interim ascertainment of rebleeds and death. The primary outcome was the proportion of patients with a modified Rankin scale (mRs) score between 3 and 6 (dependency or death) at 1 year. Trial recruitment was stopped by the steering committee after a planned interim analysis. Analysis was per protocol. One hundred and ninety of 801 (23.7%) patients allocated endovascular treatment were dependent or dead at 1 year compared with 243 of 793 (30.6%) of those allocated neurosurgical treatment (P = .0019). The relative and absolute risk reductions in dependency or death after allocation to an endovascular versus neurosurgical treatment were 22.6% (95% CI 8.9-34.2) and 6.9% (2.5-11.3), respectively. The risk of rebleeding from the ruptured aneurysm after 1 year was two per 1276 and zero per 1081 patient-years for patients allocated endovascular and neurosurgical treatment, respectively. In patients with a ruptured intracranial aneurysm, for which endovascular coiling and neurosurgical clipping are therapeutic options, the outcome in terms of survival free of disability at 1 year is significantly better with endovascular coiling. The data available to date suggest that the long-term risks of further bleeding from the treated aneurysm are low with either therapy, although somewhat more frequent with endovascular coiling.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                ranc
                Revista argentina de neurocirugía
                Rev. argent. neurocir.
                Asociación Argentina de Neurocirugía (Ciudad Autónoma de Buenos Aires, , Argentina )
                1850-1532
                September 2006
                : 20
                : 3
                : 115-120
                Affiliations
                [01] Ciudad Autónoma de Buenos Aires orgnameCentro Endovascular Neurológico Buenos Aires Argentina
                Article
                S1850-15322006000300003
                148d7322-b363-4b29-ae06-66d3aa7debd6

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : June 2006
                : March 2006
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 21, Pages: 6
                Product

                SciELO Argentina


                Tratamiento endovascular,Tope de basilar,Aneurisma cerebral,Endovascular treatment,Cerebral aneurysm,Basilar tip aneurysm

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