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      Grey matter density and GABAA binding potential show a positive linear relationship across cortical regions.

      1 , , , ,
      Neuroscience
      Elsevier BV

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          Abstract

          Voxel based morphometry (VBM) is a widely used technique for studying the structure of the brain. Direct comparisons between the results obtained using VBM and the underlying histology are limited, however. To circumvent the problems inherent in comparing VBM data in vivo with tissue samples that must generally be obtained post-mortem, we chose to consider GABAA receptors, measured using (18)F-flumazenil PET (18F-FMZ-PET), as non-invasive neural markers to be compared with VBM data. Consistent with previous cortical thickness findings, GABAA receptor binding potential (BPND) was found to correlate positively across regions with grey matter (GM) density. These findings confirm that there is a general positive relationship between MRI-based GM density measures and GABAA receptor BPND on a region-by-region basis (i.e., regions with more GM tend to also have higher BPND).

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          Author and article information

          Journal
          Neuroscience
          Neuroscience
          Elsevier BV
          1873-7544
          0306-4522
          Apr 03 2013
          : 235
          Affiliations
          [1 ] Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa, Ottawa, Canada.
          Article
          S0306-4522(13)00040-7
          10.1016/j.neuroscience.2012.12.075
          23380503
          14a490c2-19ab-4fc6-97df-8973a5bad008
          History

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