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      Call for Papers in Kidney and Blood Pressure Research: Kidney Function and Omics Science

      Submission Deadline: December 20, 2023

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      Marked Increases in Macrophage Colony-Stimulating Factor and Interleukin-18 in Maintenance Hemodialysis Patients: Comparative Study of Advanced Glycation End Products, Carboxymethyllysine and Pentosidine

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          Abstract

          Background: Recent studies have demonstrated the crucial involvement of advanced glycation end products (AGEs) in major complications of long-term hemodialysis (HD) patients. HD, in a clinical setting, is characterized by increased production of proinflammatory cytokines. AGEs and cytokines are presumed to be responsible for the development of major complications in long-term HD. We therefore investigate here the relationship between a newly identified cytokine, interleukin-18 (IL-18), and two AGEs, carboxymethyllysine-hemoglobin (CML-Hb) and pentosidine. Methods: CML-Hb, pentosidine macrophage colony-stimulating factor (M-CSF), and IL-18 were evaluated in 35 patients undergoing stable maintenance HD. CML-Hb and pentosidine were measured by a dot blot and competitive ELISA. Cytokines were measured with a cytokine-specific ELISA. Results: Circulating levels of CML-Hb and pentosidine were elevated in HD patients as compared to controls. The serum values of M-CSF and IL-18 were significantly increased in the HD patients in comparison to controls. Moreover, these two AGEs and serum values of M-CSF, M-CSF and IL-18 showed significant correlation by simple and multiple regression analysis. Conclusion: Elevation of circulating IL-18 levels was demonstrated in maintenance HD patients relative to controls. A correlative increase in M-CSF and IL-18 suggests the presence of a primed state of monocytes/macrophages in HD patients.

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          The Advanced Glycation End Product,N-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions

          John W Baynes, Min-Xin Fu, Alicia J. Jenkins … (1996)
          Article 0 comments Cited 59 times – based on 0 reviews     Review now
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            Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1  are differentially regulated in human blood mononuclear cells and mouse spleen cells

            C A Dinarello, A. Puren, G Fantuzzi (1999)
            Article 0 comments Cited 47 times – based on 0 reviews     Review now
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              Identification of pentosidine as a native structure for advanced glycation end products in beta-2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis.

              V Monnier, S. Taneda, R Kawai … (1996)
              beta-2-Microglobulin (beta-2m) is a major constituent of amyloid fibrils in patients with dialysis-related amyloidosis (DRA). Recently, we found that the pigmented and fluorescent adducts formed nonenzymatically between sugar and protein, known as advanced glycation end products (AGEs), were present in beta-2m-containing amyloid fibrils, suggesting the possible involvement of AGE-modified beta-2m in bone and joint destruction in DRA. As an extension of our search for the native structure of AGEs in beta-2m of patients with DRA, the present study focused on pentosidine, a fluorescent cross-linked glycoxidation product. Determination by both HPLC assay and competitive ELISA demonstrated a significant amount of pentosidine in amyloid-fibril beta-2m from long-term hemodialysis patients with DRA, and the acidic isoform of beta-2m in the serum and urine of hemodialysis patients. A further immunohistochemical study revealed the positive immunostaining for pentosidine and immunoreactive AGEs and beta-2m in macrophage-infiltrated amyloid deposits of long-term hemodialysis patients with DRA. These findings implicate a potential link of glycoxidation products in long-lived beta-2m-containing amyloid fibrils to the pathogenesis of DRA.
              Article 0 comments Cited 28 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): NEF
                Journal ID (nlm-ta): Nephron
                Journal ID (doi): 10.1159/issn.1660-8151
                Title: Nephron
                Publisher: S. Karger AG
                ISSN (Print): 1660-8151
                ISSN (Electronic): 2235-3186
                Publication date Subscription-year: 2002
                Publication date (Print): April 2002
                Publication date (Electronic): 08 April 2002
                Volume: 90
                Issue: 4
                Pages: 401-407
                Affiliations
                aDepartment of Laboratory Medicine, Kagoshima University School of Medicine, Kagoshima, Japan; bSuiyukai Clinic, Kashihara, Japan; cLaboratory Host Defenses, Hyogo College of Medicine, Nishinomiya, Japan; dMitsubishi Kagaku Biochemical Laboratories Inc., Tokyo, Japan; eDepartment of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan; fR&D for Diagnostics, A&T Corp., Fujisawa, Japan
                Article
                Publisher ID: 54727 Other ID: Nephron 2002;90:401–407
                DOI: 10.1159/000054727
                PubMed ID: 11961398
                SO-VID: 14b42e54-0158-451d-87c6-ad18061f5d48
                Copyright statement: © 2002 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Page count
                Figures: 5, Tables: 1, References: 33, Pages: 7
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/54727
                Self URI (text/html): https://www.karger.com/Article/FullText/54727
                Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology
                Categories
                Subject: Original Paper

                ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
                Keywords: Macrophage colony-stimulating factor,Hemodialysis,Interleukin-18,Carboxymethyllysine-hemoglobin,Pentosidin
                Data availability:
                ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
                Keywords: Macrophage colony-stimulating factor, Hemodialysis, Interleukin-18, Carboxymethyllysine-hemoglobin, Pentosidin

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