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      Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/overweight


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          Inactivated COVID-19 vaccines have been widely used to vaccinate the Chinese population. However, limited literature exists to explore the effect of obesity on the humoral and cellular immune response to these vaccines. In this study, 132 high BMI (Body mass index) (obesity and overweight, BMI ≥ 24 kg/m 2) and 82 normal BMI (BMI < 24 kg/m 2) participants were enrolled. Adverse events (AEs), Spike receptor-binding domain IgG antibody (anti-RBD-IgG), neutralizing antibodies (NAbs), and specific B-cell and T-cell responses were evaluated 21-105 days after full-course inactivated COVID-19 vaccination. The overall incidence of adverse events (AEs) was similar in individuals with and without obesity/overweight. No serious vaccine-related AEs occurred. Individuals with obesity/overweight had a reduced seropositivity rate of NAbs compared to those with normal BMI. Anti-RBD-IgG and NAbs titers in the high BMI group were significantly lower than those in the normal BMI group. The frequencies of RBD-specific memory B cells (MBCs) and the numbers of spike-specific TNF-α+ spot-forming cells (SFCs) in individuals with obesity/overweight were reduced compared with those noted in individuals without obesity/overweight. A similar trend of weakened humoral responses was also observed in individuals with central obesity. Our study results suggested that inactivated COVID-19 vaccines were safe and well tolerated but induced poor humoral and cellular immune responses in Chinese individuals with obesity/overweight.

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          Author and article information

          Genes Dis
          Genes Dis
          Genes & Diseases
          Chongqing Medical University. Production and hosting by Elsevier B.V.
          29 November 2022
          29 November 2022
          [a ] Department of Infectious Diseases , Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) , Institute for Viral Hepatitis , The Second Affiliated Hospital , Chongqing Medical University , Chongqing 400061 , China
          [b ] Health Management Center , the Second Affiliated Hospital of Chongqing Medical University , Chongqing 400061 , China
          Author notes
          []Corresponding author. No. 288, Tianwen Avenue, Chayuan, Nan'an District, Chongqing 401336, China. Tel.: +86 023 62888141. .
          [∗∗ ]Corresponding author. .

          These authors have contributed equally to this work.

          © 2022 Chongqing Medical University. Production and hosting by Elsevier B.V.

          Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

          : 19 June 2022
          : 24 August 2022
          : 23 October 2022
          Full Length Article

          covid-19,immune response,inactivated vaccine,obesity,overweight


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