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Control-Relevant Erythropoiesis Modeling in End-Stage Renal Disease
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Abstract
Anemia is prevalent in end-stage renal disease (ESRD). The discovery of recombinant
human erythropoietin (rHuEPO) over 30 years ago has shifted the treatment of anemia
for patients on dialysis from blood transfusions to rHuEPO therapy. Many anemia management
protocols (AMPs) used by clinicians comprise a set of experience-based rules for weekly-to-monthly
titration of rHuEPO doses based on hemoglobin (Hb) measurements. In order to facilitate
the design of an AMP using model-based feedback control theory, we present a physiologically
relevant erythropoiesis model and demonstrate its applicability using clinical data.