Immune Cytokine Regulation of Sympathetic Ganglion Response to Injury

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Abstract

Without appropriate response to traumatic injury, the nervous system cannot survive. The superior cervical (sympathetic) ganglion of the neonatal rat has been a uniquely valuable model system in which to study neuronal response to traumatic injury. Explantation of the ganglion into culture involves severing both presynaptic fibers (compromising preganglionic input) and axotomy (damaging efferent axons of ganglionic neurons). Since traumatic injury of any kind involves the elaboration of inflammatory cytokines, we have been interested in examining the action of these inflammatory cytokines on neurotransmitter gene expression in injured sympathetic ganglia.

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Journal ID (publisher-id): NIM

Journal ID (nlm-ta): Neuroimmunomodulation

Journal ID (doi): 10.1159/issn.1021-7401

Title: Neuroimmunomodulation

Publisher: S. Karger AG

ISSN (Print): 1021-7401

ISSN (Electronic): 1423-0216

Publication date Subscription-year: 1995

Publication date (Print): 1995

Publication date (Electronic): 08 March 1996

Volume: 2

Issue: 4

Pages: 236-240

Affiliations

Department of Biological Sciences, Rutgers University, Newark, N.J., USA

Article

Publisher ID: 97201 Other ID: Neuroimmunomodulation 1995;2:236–240

DOI: 10.1159/000097201

PubMed ID: 8963752

SO-VID: 14d652dd-aca0-4f3a-966d-3c8409c535d3

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Immune Cytokine Regulation of Sympathetic Ganglion Response to Injury

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Karger: Endocrinology

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