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      Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus.

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          Abstract

          The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly implicated in the pathophysiology of anxiety disorders. Here, we show that, dependent on their position along the dorsoventral axis of the hippocampus, DG granule cells (GCs) control specific features of anxiety and contextual learning. Using optogenetic techniques to either elevate or decrease GC activity, we demonstrate that GCs in the dorsal DG control exploratory drive and encoding, not retrieval, of contextual fear memories. In contrast, elevating the activity of GCs in the ventral DG has no effect on contextual learning but powerfully suppresses innate anxiety. These results suggest that strategies aimed at modulating the excitability of the ventral DG may be beneficial for the treatment of anxiety disorders.

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          Author and article information

          Journal
          Neuron
          Neuron
          Elsevier BV
          1097-4199
          0896-6273
          Mar 06 2013
          : 77
          : 5
          Affiliations
          [1 ] Department of Neuroscience, Columbia University, New York, NY 10032, USA.
          Article
          S0896-6273(13)00046-9 NIHMS435985
          10.1016/j.neuron.2012.12.038
          3595120
          23473324
          1501f4f3-f01f-4c19-be4e-ec5aed08629a
          Copyright © 2013 Elsevier Inc. All rights reserved.
          History

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