Tuberculosis (TB) is an infectious disease characterized by specific granular inflammation and granuloma (tuberculoma) formation. In the Slovak Republic, there were 336 cases of TB in the year 2014, which signifies a prevalence of 6.20/100,000 in the total population. The TB prevalence decreased by about 1.21/100,000 population compared to the year 2013. The proportion of extra-pulmonary TB was 59 cases to 277 cases of pulmonary TB. The highest incidence of TB in women was in the age group 0 – 4 years (19 cases), and in men in the age of 50 - 54 years (27 cases). The highest prevalence of TB was in the Presov Region (13.07/100,000) and in Kosice Region (8.05/100,000), the lowest TB prevalence was in Trnava Region (3.23/100,000). The TB prevalence in childhood was 45 cases, of which 39 cases were in Roma children. The highest prevalence of TB in childhood was in the Presov Region (22.24/100,000) and Banska Bystrica Region (4.35/100,000). The Slovak Republic reached the highest percentage of successful TB treatment (85%) in newly diagnosed microscopically positive cases among European countries. The incidence of TB in Slovakia decreased over recent years, but nevertheless, more attention should be paid to looking for patients, particularly in high-risk population groups.