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      Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.

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          Abstract

          Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and their immediate reaction to brain damage. By using in vivo two-photon imaging in neocortex, we found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions. Furthermore, blood-brain barrier disruption provoked immediate and focal activation of microglia, switching their behavior from patroling to shielding of the injured site. Microglia thus are busy and vigilant housekeepers in the adult brain.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          1095-9203
          0036-8075
          May 27 2005
          : 308
          : 5726
          Affiliations
          [1 ] Abteilung Zellphysiologie, Max Planck Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.
          Article
          1110647
          10.1126/science.1110647
          15831717
          1506ce39-f99f-4222-8025-e444f0e181ba
          History

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