- Record: found
- Abstract: found
- Article: not found
Acoustic force spectroscopy.
Gerrit Sitters
1 ,
Douwe Kamsma
1 ,
Gregor Thalhammer
2 ,
Monika Ritsch-Marte
2 ,
Erwin J G Peterman
1 ,
Gijs J L Wuite
1
Jan 2015
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.