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      Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration.

      1 ,
      Brain research
      Elsevier BV

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          Abstract

          Fluoro-Jade B, like its predecessor Fluoro-Jade, is an anionic fluorescein derivative useful for the histological staining of neurons undergoing degeneration. However, Fluoro-Jade B has an even greater specific affinity for degenerating neurons. This notion is supported by the conspicuous staining of degenerating neuronal elements with minimal background staining. This improved signal-to-noise ratio means that fine neuronal processes including distal dendrites, axons and axon terminals can be more readily detected and documented. Although the staining time and dye concentration are reduced, the method is as rapid, simple and reliable as the original Fluoro-Jade technique. Like Fluoro-Jade, Fluoro-Jade B is compatible with a number of other labeling procedures including immunofluorescent and fluorescent Nissl techniques.

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          Author and article information

          Journal
          Brain Res
          Brain research
          Elsevier BV
          0006-8993
          0006-8993
          Aug 25 2000
          : 874
          : 2
          Affiliations
          [1 ] Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, 72079-9502, Jefferson, AR 72079-9502, USA. lschmued@nctr.fda.gov
          Article
          S0006-8993(00)02513-0
          10.1016/s0006-8993(00)02513-0
          10960596
          1511c915-2bb7-40c0-96a0-78d187d0819a
          History

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