For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
18
views
34
references
 Top references
cited by
13
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      139
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Association of ABO and Rh Blood Groups to Blood-Borne Infections among Blood Donors in Tehran-Iran

      research-article

      Read this article at

      ScienceOpenPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          The aim of this study was to investigate the prevalence of hepatitis B, hepatitis C, HIV and syphilis infections in blood donors referred to Tehran Blood Transfusion Center (TBTC), and determine any association between blood groups and blood- borne infections between the years of 2005 and 2011.

          Methods

          This was a retrospective study conducted at TBTC. All of the donor serum samples were screened for HBV, HCV, HIV and syphilis by using third generation ELISA kits and RPR test. Initial reactive samples were tested in duplicate. Confirmatory tests were performed on all repeatedly reactive donations. Blood group was determined by forward and reverse blood grouping. The results were subjected to chi square analysis for determination of statistical difference between the values among different categories according to SPSS program.

          Results

          Overall, 2031451 donor serum samples were collected in 2005-2011. Totally, 10451 were positive test for HBV, HCV, HIV and syphilis. The overall seroprevalence of HBV, HCV, HIV, and syphilis was 0.39%, 0.11%, 0.005%, and 0.010%, respectively. Hepatitis B and HIV infections were significantly associated with blood group of donors ( P <0.05) ; percentage of HIV Ag/Ab was higher in donors who had blood group “A” and percentage of HBs Ag was lower in donors who had blood group O. There was no significant association between Hepatitis C and syphilis infections with ABO and Rh blood groups ( P>0.05).

          Conclusion

          Compared with neighboring countries and the international standards, prevalence of blood-borne infections is relatively low.

          Related collections

          Most cited references34

          • Record: found
          • Abstract: found
          • Article: not found

          Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

          Laufey Th Amundadottir, Peter Kraft, Rachael Z. Stolzenberg-Solomon … (2009)
          We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.
          Article 0 comments Cited 209 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis.

            Celine Choo, J Dienstag, T Miyamura … (1989)
            A specific assay has been developed for a blood-borne non-A, non-B hepatitis (NANBH) virus in which a polypeptide synthesized in recombinant yeast clones of the hepatitis C virus (HCV) is used to capture circulating viral antibodies. HCV antibodies were detected in six of seven human sera that were shown previously to transmit NANBH to chimpanzees. Assays of ten blood transfusions in the United States that resulted in chronic NANBH revealed that there was at least one positive blood donor in nine of these cases and that all ten recipients seroconverted during their illnesses. About 80 percent of chronic, post-transfusion NANBH (PT-NANBH) patients from Italy and Japan had circulating HCV antibody; a much lower frequency (15 percent) was observed in acute, resolving infections. In addition, 58 percent of NANBH patients from the United States with no identifiable source of parenteral exposure to the virus were also positive for HCV antibody. These data indicate that HCV is a major cause of NANBH throughout the world.
            Article 0 comments Cited 149 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The effect of ABO blood group on the diagnosis of von Willebrand disease.

              Jenna R. Montgomery, G. Gunn, John W. Marks … (1987)
              In order to firmly establish a normal range for von Willebrand factor antigen (vWF:Ag), we determined plasma vWF:Ag concentrations in 1,117 volunteer blood donors by quantitative immunoelectrophoresis. The presence of the ABO blood group has a significant influence on vWF:Ag values; individuals with blood group O had the lowest mean vWF:Ag level (74.8 U/dL), followed by group A (105.9 U/dL), then group B (116.9 U/dL), and finally group AB (123.3 U/dL). Multiple regression analysis revealed that age significantly correlated with vWF:Ag levels in each blood group. We then performed reverse ABO typing on stored plasma from 142 patients with the diagnosis of von Willebrand disease (vWd). Of 114 patients with type I vWd, blood group O was found in 88 (77%), group A in 21 (18%), group B in 5 (4%), and group AB in none (0%), whereas the frequency of these blood groups in the normal population is significantly different (45%, 45%, 7% and 3%, respectively) (P less than .001). Patients with type II or III vWd had ABO blood group frequencies that were not different from the expected distribution. There may be a subset of symptomatic vWd patients with decreased concentrations of structurally normal vWf (vWd, type I) on the basis of blood group O. Some individuals of blood group AB with a genetic defect of vWF may have the diagnosis overlooked because vWF levels are elevated due to blood type.
              Article 0 comments Cited 92 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Iran J Public Health
                Journal ID (iso-abbrev): Iran. J. Public Health
                Journal ID (publisher-id): IJPH
                Title: Iranian Journal of Public Health
                Publisher: Tehran University of Medical Sciences
                ISSN (Print): 2251-6085
                ISSN (Electronic): 2251-6093
                Publication date (Print): July 2014
                Volume: 43
                Issue: 7
                Pages: 981-989
                Affiliations
                [1]1. Dept. of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
                [2]2. Iranian Blood Transfusion Research Center & Tehran Blood Transfusion Center, Tehran, Iran
                [3]3. Dept. of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
                Author notes
                * Corresponding Author: Tel: 009821-82883874 Email: pourfa@ 123456modares.ac.ir
                Article
                Accession ID: IJPH-43-981
                PMC ID: 4401062
                PubMed ID: 25909065
                SO-VID: 152d3652-9bed-4db4-b211-eabd3b3198a0
                Copyright © Copyright © Iranian Public Health Association & Tehran University of Medical Sciences
                License:

                This work is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

                History
                Date received : 15 February 2014
                Date accepted : 19 May 2014
                Categories
                Subject: Original Article

                ScienceOpen disciplines: Public health
                Keywords: hbv,hcv,hiv,syphilis,abo blood groups,rhesus (rh),blood donors
                Data availability:
                ScienceOpen disciplines: Public health
                Keywords: hbv, hcv, hiv, syphilis, abo blood groups, rhesus (rh), blood donors

                Comments

                Comment on this article

                Similar content139

                See all similar

                Cited by11

                See all cited by

                Most referenced authors461

                See all reference authors