Induction and Inhibition of Ovulation in the Rat by Intracerebral Progesterone Implants

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Abstract

Depending on the moment of implantation, intra-cerebrally-placed progesterone pellets either induce or inhibit ovulation specifically if they are placed into the ventromedial nuclei of the hypothalamus. Similar implants placed in the pre-optic area, the amygdala, or the hippocampus are ineffective. Implants in the ventromedial nuclei can lengthen the ovulatory cycle by only one day. A hypothesis is presented to explain the effect of progesterone on the secretion of gonadotropins in different experimental circumstances.

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Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1974

Publication date (Print): 1974

Publication date (Electronic): 20 March 2008

Volume: 15

Issue: 1

Pages: 38-50

Affiliations

Department of Pharmacology, University of Leiden, Leiden

Article

Publisher ID: 122291 Other ID: Neuroendocrinology 1974;15:38–50

DOI: 10.1159/000122291

PubMed ID: 4368814

SO-VID: 152dcc40-10ef-4ecf-b10f-b6adf370587d

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 17 September 1973

Date accepted : 05 December 1973

Page count

Pages: 13

Induction and Inhibition of Ovulation in the Rat by Intracerebral Progesterone Implants

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Karger: Endocrinology

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