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Potassium channels and human corporeal smooth muscle cell tone: diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers.

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      Abstract

      Sustained contraction of human corporeal smooth muscle depends on continuous transmembrane calcium flux through voltage gated calcium channels. K channels modulate corporeal smooth muscle membrane potential and, thus, ultimately affect transmembrane calcium flux. Therefore, we characterized relaxation responses elicited by the K channel modulators pinacidil and levcromakalim on isolated human corporeal tissue strips. We also evaluated the possibility that there may be alterations in adenosine triphosphate sensitive K channel pharmacology/function related to the presence of diabetes mellitus.

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      Affiliations
      [1 ] Department of Urology, Institute of Smooth Muscle Biology, Albert Einstein College of Medicine, The Bronx, New York, USA.
      Journal
      J. Urol.
      The Journal of urology
      0022-5347
      0022-5347
      Jul 2002
      : 168
      : 1
      12050569
      S0022-5347(05)64920-8

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