For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
14
views
17
references
 Top references
cited by
2
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
4 collections
    0
    shares
      252
      similar
       All similar
      Call for Papers in Kidney and Blood Pressure Research: Kidney Function and Omics Science

      Submission Deadline: December 20, 2023

      Submit now

      • Record: found
      • Abstract: found
      • Article: found

      Recurrence and Recovery of COVID-19 in an Older Adult Patient with Multiple Comorbidities: A Case Report

      case-report
      Author(s): a , * , b
      Publication date (Electronic):
      Journal: Gerontology
      Publisher: S. Karger AG
      Keywords: Coronavirus disease, Recurrence, Reinfection, Older adult, Asymptomatic

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The coronavirus disease 2019 (COVID-19) pandemic has become a worldwide public health crisis since December 2019. Reports of COVID-19 recurrences are uncommon but raise the question of whether patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will develop lasting immunity against or whether there are multiple viral strains that need to be considered. Although severe disease typically occurs in older individuals with comorbidities, this case report describes a patient in this demographic group who presented with COVID-19 recurrence and remained relatively asymptomatic throughout both disease courses. This case highlights how SARS-CoV-2 appears to affect some patients unpredictably, indicating that more research is needed to further understand its viral pathophysiology and disease outcomes.

          Related collections

          Most cited references17

          • Record: found
          • Abstract: found
          • Article: not found

          Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

          Quan-Xin Long, Xiao-Jun Tang, Qiu-Lin Shi … (2020)
          The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT-PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. Asymptomatic individuals were admitted to the government-designated Wanzhou People's Hospital for centralized isolation in accordance with policy1. The median duration of viral shedding in the asymptomatic group was 19 d (interquartile range (IQR), 15-26 d). The asymptomatic group had a significantly longer duration of viral shedding than the symptomatic group (log-rank P = 0.028). The virus-specific IgG levels in the asymptomatic group (median S/CO, 3.4; IQR, 1.6-10.7) were significantly lower (P = 0.005) relative to the symptomatic group (median S/CO, 20.5; IQR, 5.8-38.2) in the acute phase. Of asymptomatic individuals, 93.3% (28/30) and 81.1% (30/37) had reduction in IgG and neutralizing antibody levels, respectively, during the early convalescent phase, as compared to 96.8% (30/31) and 62.2% (23/37) of symptomatic patients. Forty percent of asymptomatic individuals became seronegative and 12.9% of the symptomatic group became negative for IgG in the early convalescent phase. In addition, asymptomatic individuals exhibited lower levels of 18 pro- and anti-inflammatory cytokines. These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys.
          Article 0 comments Cited 1480 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients

            Kai Liu, Ying Chen, Ruzheng Lin … (2020)
            Background Due to the general susceptibility of new coronaviruses, the clinical characteristics and outcomes of elderly and young patients may be different. Objective To analyze the clinical characteristics of elderly patients with 2019 new-type coronavirus pneumonia (COVID-19). Methods This is a retrospective study of patients with new coronavirus pneumonia (COVID-19) who were hospitalized in Hainan Provincial People's Hospital from January 15, 2020 to February 18, 2020. Compare the clinical characteristics of elderly with Young and Middle-aged patients. Results A total of 56 patients were enrolled 18 elderly patients (32.14%), and 38 young and middle-aged patients (67.86%). The most common symptoms in both groups were fever, followed by cough and sputum. Four patients in the elderly group received negative pressure ICU for mechanical ventilation, and five patients in the young and middle-aged group. One patient died in the elderly group (5.56%), and two patients died in the young and middle-aged group (5.26%). The PSI score of the elderly group was higher than that of the young and middle-aged group (P < 0.001). The proportion of patients with PSI grades IV and V was significantly higher in the elderly group than in the young and middle-aged group (P < 0.05). The proportion of multiple lobe involvement in the elderly group was higher than that in the young and middle-aged group (P < 0.001), and there was no difference in single lobe lesions between the two groups. The proportion of lymphocytes in the elderly group was significantly lower than that in the young and middle-aged group (P < 0.001), and the C-reactive protein was significantly higher in the young group (P < 0.001). The Lopinavir and Ritonavir Tablets, Chinese medicine, oxygen therapy, and mechanical ventilation were statistically different in the elderly group and the young and middle-aged group, and the P values were all <0.05. Interpretation The mortality of elderly patients with COVID-19 is higher than that of young and middle-aged patients, and the proportion of patients with PSI grade IV and V is significantly higher than that of young and middle-aged patients. Elderly patients with COVID-19 are more likely to progress to severe disease.
            Article 0 comments Cited 651 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing

              Kelvin Kai-Wang To, Ivan Hung, Jonathan Daniel Ip … (2020)
              Abstract Background Waning immunity occurs in patients who have recovered from COVID-19. However, it remains unclear whether true re-infection occurs. Methods Whole genome sequencing was performed directly on respiratory specimens collected during two episodes of COVID-19 in a patient. Comparative genome analysis was conducted to differentiate re-infection from persistent viral shedding. Laboratory results, including RT-PCR Ct values and serum SARS-CoV-2 IgG, were analyzed. Results The second episode of asymptomatic infection occurred 142 days after the first symptomatic episode in an apparently immunocompetent patient. During the second episode, there was serological evidence of elevated C-reactive protein and SARS-CoV-2 IgG seroconversion. Viral genomes from first and second episodes belong to different clades/lineages. Compared to viral genomes in GISAID, the first virus genome has a stop codon at position 64 of orf8 leading to a truncation of 58 amino acids, and was phylogenetically closely related to strains collected in March/April 2020, while the second virus genome was closely related to strains collected in July/August 2020. Another 23 nucleotide and 13 amino acid differences located in 9 different proteins, including positions of B and T cell epitopes, were found between viruses from the first and second episodes. Conclusions Epidemiological, clinical, serological and genomic analyses confirmed that the patient had re-infection instead of persistent viral shedding from first infection. Our results suggest SARS-CoV-2 may continue to circulate among the human populations despite herd immunity due to natural infection or vaccination. Further studies of patients with re-infection will shed light on protective correlates important for vaccine design.
              Article 0 comments Cited 374 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Gerontology
                Journal ID (iso-abbrev): Gerontology
                Journal ID (publisher-id): GER
                Title: Gerontology
                Publisher: S. Karger AG (Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.com )
                ISSN (Print): 0304-324X
                ISSN (Electronic): 1423-0003
                Publication date (Electronic): 19 March 2021
                Pages: 1-4
                Affiliations
                [1] aSchool of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA
                [2] bDivision of Geriatric Medicine, Virginia Commonwealth University Health System, West Hospital, Richmond, Virginia, USA
                Author notes
                *Shannon Leung, Virginia Commonwealth University Health System, Division of Geriatrics, Department of Internal Medicine, 1200 E Broad St, Box 980055, 23298 Richmond, VA (USA), leungsj@ 123456vcu.edu
                Article
                Publisher ID: ger-0001
                DOI: 10.1159/000514675
                PMC ID: 8089439
                PubMed ID: 33744883
                SO-VID: 154159c7-632a-40c7-9579-7147b8941010
                Copyright statement: Copyright © 2021 by S. Karger AG, Basel
                License:

                This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

                History
                Date received : 28 October 2020
                Date accepted : 23 January 2021
                Page count
                Figures: 1, References: 10, Pages: 4
                Categories
                Subject: Clinical Section: Case Report

                Keywords: coronavirus disease,recurrence,reinfection,older adult,asymptomatic
                Data availability:
                Keywords: coronavirus disease, recurrence, reinfection, older adult, asymptomatic

                Comments

                Comment on this article

                scite_

                Similar content252

                See all similar

                Cited by2

                See all cited by

                Most referenced authors286

                See all reference authors