Autoantibodies to Cardiolipin and Beta-2-Glycoprotein-I in Coronary Artery Disease Patients with and without Hypertension

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Abstract

Background: Autoantibodies to cardiolipin (aCL) and β<sub>2</sub>-glycoprotein-I (β2GPI) are considered proatherogenic. Elevated levels of both antibodies have been reported in hypertension. Nonetheless, there are no data regarding an association between these autoantibodies and hypertension in coronary artery disease. Methods: The levels of aCL and anti-β2GPI antibodies were measured in patients having coronary artery disease with (n = 82) or without (n = 36) hypertension, in association with other major risk factors for coronary artery disease. Results: The levels of aCL and anti-β2GPI antibodies were (OD at 405 nm) 0.23 ± 0.14 and 0.22 ± 0.12 in the normal blood pressure group, as opposed to 0.24 ± 0.12 and 0.20 ± 0.12 in the hypertensive group, respectively (p = 0.67; 0.42). No significant difference in either antibody levels was found between hypertensive patients with normal and abnormal blood pressure measurements. The presence of additional risk factors did not affect antibody levels in normotensive patients. However, in the hypertensive group, the presence of smoking was associated with significantly decreased anti-β2GPI antibody levels, whereas no change was found in aCL. Further, patients who had hypertension, smoking and hypercholesterolemia, had significantly decreased anti-β2GPI antibody levels compared with patients without any of these risk factors (0.13 ± 0.04 versus 0.23 ± 0.13, respectively; p = 0.02). Conclusion: Hypertension is not associated with modification of aCL and anti-β2GPI antibody levels in coronary artery disease patients. However, there are elevated anti-β2GPI antibody levels in patients without conventional risk factors compared with patients with these risk factors.

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Antibodies to Beta 2 -Glycoprotein I in Ischemic Stroke

Paolo Fiallo, Carlo Tomasina, Andrea Clapasson … (2000)

Antibodies to β 2 -glycoprotein (β 2 -GPI) have been associated with recurrent thrombotic events in patients with systemic lupus erythematosus. The present study investigated the prevalence of antibodies to β 2 -GPI in an unselected group of patients with ischemic stroke. One hundred and twenty-one sera from patients with ischemic stroke and 174 control sera from patients with nonischemic neurological disorders (n = 43) and healthy subjects (n = 131) were tested for antibodies to β 2 -GPI by a solid-phase ELISA. Twenty-nine stroke patients (24%) had antibodies to β 2 -GPI. Of the 43 patients in the neurological control group, 2 were positive. For comparison between the groups, Fisher’s exact test was used for categorical variables and ANOVA for antibody titers. Antibody levels and frequencies of positivity were significantly different between the study groups. None of the sera from the healthy control group had abnormal antibody levels. When risk factors and associated diseases were taken into account, a marginal association was found between the presence of antibodies to β 2 -GPI and hypertension (p = 0.036). This study demonstrates a significant prevalence of antibodies to β 2 -GPI in an unselected stroke population.

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Autoantibodies to oxidized low-density lipoprotein in coronary artery disease

Y SHERER (2001)

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Author and article information

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 2002

Publication date (Print): March 2002

Publication date (Electronic): 07 March 2002

Volume: 97

Issue: 1

Pages: 2-5

Affiliations

^aDepartment of Medicine B and Center of Autoimmune Diseases, ^bCardiac Rehabilitation Institute, Sheba Medical Center, Tel-Hashomer, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

Article

Publisher ID: 47411 Other ID: Cardiology 2002;97:2–5

DOI: 10.1159/000047411

PubMed ID: 11893822

SO-VID: 155c2fa0-5f18-4f09-994c-830ad155c140

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