0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Abacavir/lamivudine combination in the treatment of HIV: a review

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Abacavir has been at the center of research and clinical interest in the last two years. The frequency of the associated abacavir hypersensitivity syndrome has decreased substantially since the introduction of routine testing for the HLA-B*5701 allele; the activity of the drug in HIV-infected persons with HIV RNA values more than 100,000 copies/mL has been questioned; the possible increased risk of myocardial infarction after recent exposure to abacavir has been debated; and the drug has been moved from the “recommended” category to the “alternative” category in several guidelines. Still, the drug remains a useful agent in combination with other drugs, including lamivudine, for the treatment of HIV infection. This review will focus on the pharmacokinetics, activity, side effects, and resistance profile of both abacavir and lamivudine, including a thorough review of all of the recent studies relevant to both drugs.

          Related collections

          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2010
          2010
          3 March 2010
          : 6
          : 83-94
          Affiliations
          [1 ]Division of Infectious Diseases, Wayne State University, Detroit, MI, USA;
          [2 ]University of Pittsburgh Medical Center, Shadyside Hospital, Pittsburgh, OH, USA
          Author notes
          Correspondence: Rodger D MacArthur, Division of Infectious Diseases, Wayne State University, Detroit, MI, USA, Tel +1 313-993-0930, Email rmacarthur@ 123456med.wayne.edu
          Article
          tcrm-6-083
          2835563
          20234788
          © 2010 Sivasubramanian et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Review

          Medicine

          abacavir, hiv, lamivudine

          Comments

          Comment on this article