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      Helicobacter pylori update: gastric cancer, reliable therapy, and possible benefits.

      1
      Gastroenterology
      Elsevier BV
      Bacteria, Barrett's Esophagus, Esophageal Adenocarcinoma, Prevention, Stomach Cancer

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          Abstract

          Helicobacter pylori infection contributes to the development of diverse gastric and extragastric diseases. The infection is necessary but not sufficient for the development of gastric adenocarcinoma. Its eradication would eliminate a major worldwide cause of cancer death, therefore there is much interest in identifying how, if, and when this can be accomplished. There are several mechanisms by which H pylori contributes to the development of gastric cancer. Gastric adenocarcinoma is one of many cancers associated with inflammation, which is induced by H pylori infection, yet the bacteria also cause genetic and epigenetic changes that lead to genetic instability in gastric epithelial cells. H pylori eradication reduces both. However, many factors must be considered in determining whether treating this bacterial infection will prevent cancer or only reduce its risk-these must be considered in designing reliable and effective eradication therapies. Furthermore, H pylori infection has been proposed to provide some benefits, such as reducing the risks of obesity or childhood asthma. When tested, these hypotheses have not been confirmed and are therefore most likely false.

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          Author and article information

          Journal
          Gastroenterology
          Gastroenterology
          Elsevier BV
          1528-0012
          0016-5085
          Apr 2015
          : 148
          : 4
          Affiliations
          [1 ] Department of Medicine, Michael E. DeBakey VA Medical Center, and Baylor College of Medicine, Houston, Texas. Electronic address: dgraham@bcm.edu.
          Article
          S0016-5085(15)00158-4 NIHMS660812
          10.1053/j.gastro.2015.01.040
          4375058
          25655557
          1568082b-8a88-4a5a-b548-1d5caae904e6
          Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.

          Bacteria,Barrett's Esophagus,Esophageal Adenocarcinoma,Prevention,Stomach Cancer

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