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      Effect of estradiol and ethynylestradiol on microtubule distribution in Chinese hamster V79 cells.

      Chemical & pharmaceutical bulletin

      Animals, Cell Line, Cricetinae, Cricetulus, Estradiol, pharmacology, Ethinyl Estradiol, Microtubules, drug effects

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          Abstract

          The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 microM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

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          1576671

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