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      Endothelial function in health and disease: new insights into the genesis of cardiovascular disease

      The American Journal of Medicine
      Elsevier BV

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          Abstract

          The vascular endothelium secretes factors that not only modulate blood vessel tone, but also participate in the development and progression of atherosclerosis through their effects on platelet adhesion and aggregation, thrombogenicity, and cell proliferation. Altered activities of these substances in patients with risk factors for cardiovascular disease (e.g., hypercholesterolemia, hypertension, diabetes, aging, postmenopausal status, smoking, and infections) appear to underlie the atherosclerotic process. There is increasing evidence from both preclinical studies and clinical trials that nitric oxide (NO) plays a pivotal role in the pathophysiology of arteriosclerosis. This review describes the role of NO in human health and disease and summarizes strategies currently being used to measure and improve endothelial dysfunction.

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          Author and article information

          Journal
          The American Journal of Medicine
          The American Journal of Medicine
          Elsevier BV
          00029343
          July 1998
          July 1998
          : 105
          : 1
          : 32S-39S
          Article
          10.1016/S0002-9343(98)00209-5
          9707266
          157af05f-ef06-4c8a-8716-5fd6a7422e50
          © 1998

          https://www.elsevier.com/tdm/userlicense/1.0/

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