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      Fabrication, modification, and biomedical applications of anodized TiO2 nanotube arrays

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          Abstract

          Recent research activities on the surface modification and biomedical applications of TiO 2 NTAs are reviewed.

          Abstract

          Titanium dioxide (TiO 2) nanotubes have attracted increasing attention due to their outstanding properties and potential applications in photocatalysis, dye-sensitized solar cells, and biomedical devices. In this paper, recent research progress on TiO 2 nanotube arrays (NTAs) produced by anodic oxidation of Ti in fluoride-containing electrolytes is reviewed with emphasis on the modification methods and biomedical applications. The fabrication protocol and growth mechanism are first discussed and common modification methods used to improve the optical, electronic, and biomedical properties of TiO 2 NTAs are reviewed. Photo/electro-chemical biosensors based on TiO 2 NTAs dedicated to the detection of glucose, hydrogen peroxide, and other biomolecules are described and recent examples of using TiO 2 NTAs to improve the cellular response in vitro and accelerate osseointegration in vivo are provided. The incorporation and delivery of inorganic bioactive agents such as Ag, Sr, and Zn to achieve antibacterial and/or osteogenesis inducing ability are described and finally, the outlook and future development of TiO 2 nanotubes pertaining to biomedical devices are briefly discussed.

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          Most cited references 183

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          A review on highly ordered, vertically oriented TiO2 nanotube arrays: Fabrication, material properties, and solar energy applications

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            TiO2 photocatalysis: Design and applications

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              Bone tissue engineering: state of the art and future trends.

              Although several major progresses have been introduced in the field of bone regenerative medicine during the years, current therapies, such as bone grafts, still have many limitations. Moreover, and in spite of the fact that material science technology has resulted in clear improvements in the field of bone substitution medicine, no adequate bone substitute has been developed and hence large bone defects/injuries still represent a major challenge for orthopaedic and reconstructive surgeons. It is in this context that TE has been emerging as a valid approach to the current therapies for bone regeneration/substitution. In contrast to classic biomaterial approach, TE is based on the understanding of tissue formation and regeneration, and aims to induce new functional tissues, rather than just to implant new spare parts. The present review pretends to give an exhaustive overview on all components needed for making bone tissue engineering a successful therapy. It begins by giving the reader a brief background on bone biology, followed by an exhaustive description of all the relevant components on bone TE, going from materials to scaffolds and from cells to tissue engineering strategies, that will lead to "engineered" bone. Scaffolds processed by using a methodology based on extrusion with blowing agents.
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                Author and article information

                Journal
                RSCACL
                RSC Adv.
                RSC Adv.
                Royal Society of Chemistry (RSC)
                2046-2069
                2014
                2014
                : 4
                : 33
                : 17300-17324
                Affiliations
                [1 ]Department of Physics and Materials Science
                [2 ]City University of Hong Kong
                [3 ]Kowloon, China
                [4 ]Wuhan National Laboratory for Optoelectronics
                [5 ]Huazhong University of Science and Technology
                [6 ]School of materials and metallurgy
                [7 ]Wuhan University of Science and Technology
                [8 ]Wuhan 430081, China
                [9 ]State Key Laboratory of Military Stomatology
                [10 ]Department of Periodontology
                [11 ]School of Stomatology
                [12 ]The Fourth Military Medical University
                [13 ]Xi'an 710032, China
                Article
                10.1039/C4RA01458H
                © 2014
                Product
                Self URI (article page): http://xlink.rsc.org/?DOI=C4RA01458H

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