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      Quantification of Nitric Oxide and Cytokines in Rabbit Aqueous Humor after Neodymium:YAG Laser Capsulotomy

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          Abstract

          Purpose: The purpose of this study was to evaluate the presence of nitric oxide (NO) and cytokines such as interleukin 1β, interleukin 2 receptor (IL-2R), interleukin 6 and tumor necrosis factor α on aqueous humor after neodymium:YAG (Nd:YAG) laser posterior capsulotomy. Methods: Fifteen rabbits (30 eyes) with dense posterior capsule opacities underwent Nd:YAG capsulotomy 4 months after phacoemulsification cataract surgery. After general and topical anesthesia, Nd:YAG capsulotomy was performed using an equal number of shots and power setting on all eyes. Aqueous humor specimens were collected from each eye preoperatively and at 12, 24 and 48 h after the surgery to determine NO and cytokine levels. Results: The levels of NO and cytokines except IL-2R were significantly high as compared to preoperative levels in all eyes at 12 and 24 h postoperatively (p < 0.05). Although the levels of NO and cytokines were higher than preoperative levels at 48 h, the differences were not statistically significant (p > 0.05). Conclusion: These findings suggest that NO and cytokines appear to be potential inflammatory mediators in the occurrence of early inflammation following Nd:YAG posterior capsulotomy.

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          Posterior capsule opacification

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            Multiple actions of interleukin 6 within a cytokine network.

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              Author and article information

              Journal
              ORE
              Ophthalmic Res
              10.1159/issn.0030-3747
              Ophthalmic Research
              S. Karger AG
              0030-3747
              1423-0259
              2000
              June 2000
              10 April 2000
              : 32
              : 2-3
              : 106-109
              Affiliations
              Departments of aOphthalmology and bBiochemistry, Turgut Ozal Medical Center, University of Inonu School of Medicine, Malatya, Turkey
              Article
              55598 Ophthalmic Res 2000;32:106–109
              10.1159/000055598
              10754443
              © 2000 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Tables: 1, References: 30, Pages: 4
              Categories
              Original Paper

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