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      Quantification of Nitric Oxide and Cytokines in Rabbit Aqueous Humor after Neodymium:YAG Laser Capsulotomy

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          Purpose: The purpose of this study was to evaluate the presence of nitric oxide (NO) and cytokines such as interleukin 1β, interleukin 2 receptor (IL-2R), interleukin 6 and tumor necrosis factor α on aqueous humor after neodymium:YAG (Nd:YAG) laser posterior capsulotomy. Methods: Fifteen rabbits (30 eyes) with dense posterior capsule opacities underwent Nd:YAG capsulotomy 4 months after phacoemulsification cataract surgery. After general and topical anesthesia, Nd:YAG capsulotomy was performed using an equal number of shots and power setting on all eyes. Aqueous humor specimens were collected from each eye preoperatively and at 12, 24 and 48 h after the surgery to determine NO and cytokine levels. Results: The levels of NO and cytokines except IL-2R were significantly high as compared to preoperative levels in all eyes at 12 and 24 h postoperatively (p < 0.05). Although the levels of NO and cytokines were higher than preoperative levels at 48 h, the differences were not statistically significant (p > 0.05). Conclusion: These findings suggest that NO and cytokines appear to be potential inflammatory mediators in the occurrence of early inflammation following Nd:YAG posterior capsulotomy.

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          Posterior capsule opacification

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            Multiple actions of interleukin 6 within a cytokine network.


              Author and article information

              Ophthalmic Res
              Ophthalmic Research
              S. Karger AG
              June 2000
              10 April 2000
              : 32
              : 2-3
              : 106-109
              Departments of aOphthalmology and bBiochemistry, Turgut Ozal Medical Center, University of Inonu School of Medicine, Malatya, Turkey
              55598 Ophthalmic Res 2000;32:106–109
              © 2000 S. Karger AG, Basel

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              Page count
              Tables: 1, References: 30, Pages: 4
              Original Paper


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